Dr. Sears’ ZoneRx Shakes – Vanilla (30 servings)

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(11 customer reviews)

ZoneRx Shakes are the ideal meal replacement formulated with balanced nutrition to help you feel fuller longer. Each shake is designed for maximum satiety and optimal gut health with the inclusion of high levels of polyphenols, prebiotics, and the right balance of protein to low-glycemic carbohydrates.

With a classic vanilla flavor and great taste, this shake is easy to insert at any meal during the day. Once you add milk, you’ll quickly see this is no ordinary shake with its distinct purple color.  This is due to the presence of maqui berry, our proprietary polyphenol extract. Plus, these are the first shakes to include cocoa polyphenols without the heavy metals found in expensive dark chocolate. This is only possible because one of our key ingredients is the use CacaoRx, our proprietary cocoa extract.

Our 30 serving canister is a great way to save! Rest assured knowing you have a delicious, quick and easy meal on hand every day of the month.

What makes each ZoneRx Shake unique?

  • MaquiRx® and CacaoRx™ – Our proprietary polyphenol extracts provide 250 milligrams of polyphenols to help activate genes that may reduce oxidative stress, inflammation and the rate of aging*.
  • Fortified with prebiotics – Enjoy superior appetite control and gut health support.
  • 16 Grams of Protein— Balanced with low-glycemic carbohydrates to help support stable blood sugar control.
  • 23 Vitamins and Minerals — Provides a complete meal replacement without the need to add anything additional.
  • No Added Sugar — newly reformulated to contain allulose, a natural low-calorie sweetener that helps support better blood sugar control compared to fructose.

ZoneRx Shakes use Controlled Release Nutrition to help control hunger and satiety giving you four to five hours of appetite suppression. The balance of protein to low-glycemic carbohydrates helps control hormones in the gut, brain, and the blood*. This is the foundation of the Zone Diet and is enhanced by the presence of prebiotics and polyphenols.

If you want optimal wellness, you need a lifetime strategy and products that deliver results you can see, feel and test.  The ZoneRx shakes are part of that dietary strategy. We call it Evidence-based Wellness®.

Serving Suggestions

To promote an even better gut health response, we suggest mixing 1 scoop of ZoneRx Shake mix with 10 ounces of 2% lactose-free milk in place of water and adding 1 Zone block of berries (about 1 cup). Lactose free milk provides complex sugars not found in plant sources that promote an even greater gut health response by supporting the growth of friendly bacteria while maintaining the balance of protein and low-glycemic carbohydrates needed for maximum Controlled Release Nutrition. The absence of lactose in the product will eliminate any digestive problems for individuals with even the slightest amount of lactose intolerance. The use of berries gives the ZoneRx Shakes even better glycemic control and gut health benefits with the polyphenols and fiber they contain.

30 Servings Per Container

*Vanilla currently not available in the 10 serving size.

5/5 (1 Review)

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  • Science
  • Ingredients
  • Reviews (11)
  • Q&A

Appetite suppression requires both stable blood sugar control and a healthy gut to be working in unison. Our new ZoneRx shakes do both with their combination of a balanced protein to low glycemic carbohydrate ratio plus the inclusion of 250mg of highly-purified polyphenol extracts needed for optimal gut health.

How ZoneRx Shakes work…

Our Controlled Release NutritionÒ technology helps support stable blood sugar levels with the balance of protein to the glycemic load in each food product we produce. That basic concept of Controlled Release Nutrition is now enhanced with high levels of purified polyphenol extracts to promote optimal gut health (1,2) *. Now you have a 1-2 punch for hours of appetite control with unrivaled taste and convenience. If you aren’t hungry, you eat fewer calories. If you eat fewer calories, you lose excess body fat. If you lose excess body fat, your blood pressure, blood sugar, and blood lipids will improve. It’s that easy when you are in the Zone.  The ZoneRx shakes make it easier to get there.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease

  1. Sears B and Ricordi C. “Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome, and diabetes.”  Eur Rev Med Pharmacol Sci 16:1137-1154 (2012)
  2. Sears B. “Polyphenols: Novel applications in human health.”  CellR4 5:e2437 (2017)


11 reviews for Dr. Sears’ ZoneRx Shakes – Vanilla (30 servings)

  1. Linda B.

    I was diagnosed with cancer in December 2021. It was an early detection but an aggressive cancer. Surgery removed the cancerous polyp but because of the aggressiveness of the cancer I am going through 6 chemo treatments and 3 radiation treatments. I investigated the changes I should expect and what to do about them. One thing I was told was to expect a change in my eating habits. They advised 6 small meals instead of 3 bigger ones. That need turned out to be true for me… a feat that sounds easy, but after 71 years of eating 3 meals a day it was not so simple. I thought of the Zone shakes and bought a container of Vanilla and another of Chocolate. I make one shake and either have it as a meal replacement or have a small amount here and there on the most difficult days. It’s making this experience more tolerable, manageable, and tasty. Both are delicious and very convenient. Using the 2% Lactose Free milk makes the shake bubbly and creamy. The shakes have been very helpful. Thank you.

  2. Philip Hernon

    I am allergic to stevia……I returned the product

  3. Christine Gray-DeZarn

    I like the shake in general, but I would like to understand why you put maltodextrin in your shake? This is higher GI than sucrose, correct? It seems like an unnecessary ingredient, no upside and a big downside. Can you please provide the rationale?

    • Dr. Sears Zone

      Christine, Thank you for your comment and question. The maltodextrin in the Zone Shakes is in very small amounts and used as an anti-caking agent to help prevent clumping and it is not used as a sweetener. The Vanilla ZoneRx Shakes have zero added sugar with the primary sweetener being allulose which is a natural low-calorie sweetener that helps support better blood sugar control compared to fructose which we previously used as the sweetener in the shakes. Hope this helps you out and please let us know if you have any additional questions. Dr. Sears Zone

  4. Robert J Sanchez

    I would like to try these shakes but I am worried about blood sugar spikes. I am a type 2 diabetic.

    • Dr. Sears Zone

      Robert, Thank you for your comment and we appreciate your concern. Every product we make has the goal of helping to stabilize blood sugar levels while controlling hunger and fatigue. Even though a product may contain carbohydrates like sugar it’s important to look at how it is balanced with protein and fat to impact the overall glycemic load of a meal. The parameters we use to design the shakes are in line with the macronutrient profile recommended by the Joslin Diabetes Institute at Harvard Medical School to help with blood sugar control. That said, we know every body is different in regards to how it reacts to sugar so we do offer a 100% money back guarantee if you decide to try the shakes and for some reason they don’t work for you. Maybe start with half a shake and use it as a snack to see how it works and if your happy with your numbers use the full serving as a meal replacement instead. Thank You, Dr. Sears Zone

  5. Judy McKinney

    We use these shakes 2-3 times a week. They hold off hunger and provide energy for 4-5 hours. The taste is great with none of the aftertaste of artificially sweetened shake mixes.

  6. regine

    What exactly are the ingredients? I am allergic to soy and almonds, nuts.

    • Zone Customer Support

      Regine, Thank you for your comment/question. To access the ingredients you can click on the image of the label below the main product image or click on the ingredients tab. The shakes do contain soy but they do not contain nuts or almonds. Thank You, Dr. Sears’ Zone

  7. Cheryl (verified owner)

    I don’t drink milk so I mix it with coconut milk. I dont get 5 hours, naybe 3, so I wish there was an alternative. Thats my problem in general with the Zone, id you dont eat dairy and soy, there are few other choices.

    • Zone Customer Support

      Cheryl, Thank you for your comment. If you choose to use a dairy alternative to replace the 2% Lactose Free Milk Dr. Sears recommends utilizing 10 oz. of Unsweetened Almond Milk (although the coconut milk can also work – just be sure it is unsweetened to avoid added sugars) and include 1 oz. or 22 Almonds on the side to replace the missing protein from the milk. Another option (if you do not have extra almonds handy) would be to utilize 1 ½ scoops of the shake powder rather than just 1 scoop to provide the additional protein. That should keep you feeling full longer. Thank You, Dr. Sears’ Zone Customer Support

  8. David

    A Zone shake is often my lunch in the midst of busy days. I alternate vanilla and strawberry through the week often adding fresh or frozen fruits. Easy to make, delicious and satisfying to drink. So convenient.

  9. Glenn Kouns (verified owner)

    Great taste, filling, and keeps my wife and I going throughout the day. I have a real estate business and she is a middle school teacher. During the day it is hard to get time for good lunch and the shakes provide an excellent choice for our lifestyle.

  10. David N. (verified owner)

    Wonderful flavor. I purchased vanilla but usually add blueberries or other fruit ore even peanut butter. It replaces one meal per day, usually lunch but today, breakfast.Very digestible. I cannot tolerate dairy but no problems with you shake. Thank you so much.

  11. Zack G. (verified owner)

    Tastes like a vanilla milkshake and provides hours of satiety! Incredibly convenient to have all the key nutrients needed for gut health in a shake format.

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Why Do ZoneRx Shakes Look Purple?

The purple color, most notable in the vanilla shakes comes from the presence of the highly purified polyphenol extract derived from the maqui berry. Maqui berry contains the highest levels of a special class of polyphenols known as delphinidins.  These are the same polyphenols that give red wine its color.

I’m not lactose intolerant do I still need to use lactose-free milk?

We suggest using 10oz of 2% lactose-free milk in place of water or milk alternatives even if you don’t have issues with lactose.  Many individuals may have a low-level sensitivity to lactose even if they aren’t lactose intolerant, so the complete removal of lactose can only help to improve gut health (1).

Lactose-free milk is rich in complex sugars similar to those found in human breast milk.  These complex sugars are not found in plant sources and thus provide the ideal nutrition to generate more beneficial species of bacteria in our gut.

  1. Grand RJ, Montgomery RK, Chitkara DK, and Hirschhorn JN. Changing genes; losing lactase gut 52: 617–619 (2003)

Is the ZoneRx Shake Mix Lactose-Free?

Yes, the ZoneRx Shake mix is lactose-free.  The lactose found in standard whey and milk protein sources has been totally removed by ultrafiltration.  These are known as isolates because of the removal of lactose.  This is a complex process, but essential for optimal gut health.

If you use the ZoneRx Shakes, do you still need to supplement with polyphenols?

Dr. Sears believes that individuals should consume at least 1,000 mg of polyphenols per day for wellness and athletic performance and about 1,500 mg per day for anti-aging to help with stimulation of AMP kinase*.  To get those levels, one would need to eat about 10 servings of non-starchy vegetables and fruits. Reaching those levels with food alone is difficult.  Furthermore, many of the sources rich in polyphenols either have pesticide contamination or heavy metal contamination.  For example, strawberries and spinach are good sources of polyphenols, but each is often rich in pesticides.  Cocoa powder which is the basic component of chocolate products is often rich in the heavy metal cadmium.  The polyphenols we use in the ZoneRx shakes are highly purified polyphenol extracts that have GRAS status meaning they have passed strict testing to be able to be used in food products.  Virtually no other polyphenol extract available has this designation.  Although we are the only company to list the levels of polyphenols in all of our polyphenol-enriched products, it is the type of polyphenols in those products that makes a difference.  The polyphenol extracts used in the ZoneRx Shakes is a combination of a chromatographically purified Maqui berry extract, rich in delphinidins to help support improved blood sugar control, and cadmium-free cocoa extracts that help support improved blood flow and reduction of insulin resistance.  Both of these polyphenol extracts have been supported by clinical studies (1).

  1. Sears B. “Polyphenols: Novel applications in human health.”  CellR4 5:e2437 (2017)

Are ZoneRx Shakes Gluten Free?

Yes, the ZoneRx shakes are gluten-free.  Unless someone has true celiac disease, gluten should not be a concern as Dr. Sears and vast majority of the gut research community believes that individuals who are “gluten sensitive” may actually have sensitivity to FODMAPs (Fermentable Oligo-, Di- and Monosaccharides And Polyols (1).

  1. Muir JG and Gibson PR. The Low FODMAP Diet for Treatment of Irritable Bowel Syndrome and Other Gastrointestinal Disorders. Gastroenterol Hepatol 9: 450–452 (2013)

Are ZoneRx Shakes non-GMO?

Yes, the ZoneRx shakes are non-GMO.

What Allergens do the ZoneRx Shakes include?

The ZoneRx shakes do contain milk and soy. These come from the milk fractions that supply the protein and the soy lecithin used as an emulsifier in ZoneRx Shake.  The whey protein isolate and milk protein isolate used the ZoneRx Shake are both lactose-free.  They are more expensive, but provide a far better quality of both proteins with significantly less potential effects on gut health since lactose-free products also low in FODMAPs.

What are the sources of prebiotics in ZoneRx?

Prebiotics are the fermentable fibers essential for gut health.  The sources of prebiotics in ZoneRx come from a variety of natural fermentable fibers including guar gum, inulin, oat fiber, fructo-oligo saccharides, and a synthetic resistant starch (Fiber-Sol).  These fermentable fibers are required to supply the necessary energy and metabolites (such as short chain fatty acids) for maintenance of gut barrier integrity to help prevent a leaky gut*.  However, without adequate levels of polyphenols present at the same time, optimal gut health will not be achieved.

Does the cocoa in ZoneRx contain caffeine?

The cocoa extract used in ZoneRx Shakes is a highly purified to reduce heavy metals, such as cadmium, while simultaneously increasing its polyphenol content.   There is some caffeine in the cocoa polyphenol extract, but in very low concentrations, and when this is diluted in the final shake it represents far less caffeine than found in a cup of decaffeinated coffee.

Are ZoneRx Shakes suitable for children?

ZoneRx Shakes are ideal for children as they are balanced in protein and carbohydrate, plus they contain both polyphenols and fermentable fiber (i.e. prebiotics) that promote a healthy gut. We might suggest using ½ a scoop and 5oz of lactose-free milk for small children because of their smaller size.

Do ZoneRx Shakes contain artificial sweeteners?

No. Artificial sweeteners can cause adverse changes in the microbial composition of the gut. The only sweeteners used in ZoneRx Shake are natural sweeteners such as allulose, monk fruit and stevia.

What is allulose and why did it replace fructose as the primary sweetener in the ZoneRx Shakes?

Allulose is a natural low-calorie sweetener that has a similar sweet taste to real sugar. Allulose has the same chemical formula as fructose, but it is arranged differently. Why we prefer it to fructose is that this difference in structure prevents your body from metabolizing allulose the same way as fructose, making it a low-calorie sweetener that provides more health benefits. This further improves the hormonal and appetite control of the ZoneRx Shakes to make them an even more ideal meal replacement.

Why do you include soy in the shakes?

Zone shakes contain soy lecithin which is exceptionally low in isoflavones and used as an emulsifier to help with texture and creaminess.