Dr. Sears’ ZoneRx Shakes – Vanilla (10 servings)

Price: $41.95

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(7 customer reviews)

ZoneRx Shakes are the ideal meal replacement formulated with balanced nutrition to help you feel fuller longer. Each shake is designed for maximum satiety and optimal gut health with the inclusion of high levels of polyphenols, prebiotics, and the right balance of protein to low-glycemic carbohydrates.

With a classic vanilla flavor and great taste, this shake is easy to insert at any meal during the day. Once you add milk, you’ll quickly see this is no ordinary shake with its distinct purple color. This is due to the presence of maqui berry, our proprietary polyphenol extract. Plus, these are the first shakes to include cocoa polyphenols without the heavy metals found in expensive dark chocolate. This is only possible because one of our key ingredients is the use CacaoRx, our proprietary cocoa extract.

Our convenient 10 serving canister is a great way to sample the flavor and can easily be combined with our other two flavors for a full month of variety. Mornings never tasted so good!

What makes each ZoneRx Shake unique?

  • MaquiRx® and CacaoRx™— Our proprietary polyphenol extracts provide 250 milligrams of polyphenols to help activate genes that may reduce oxidative stress, inflammation and the rate of aging*.
  • Fortified with prebiotics— Enjoy superior appetite control and gut health support.
  • 16 Grams of Protein— Balanced with low-glycemic carbohydrates to help support stable blood sugar control.
  • 24 Vitamins and Minerals — Provides a complete meal replacement without the need to add anything additional.
  • No Added Sugar — newly reformulated to contain allulose, a natural low-calorie sweetener that helps support better blood sugar control compared to fructose.

ZoneRx Shakes use Controlled Release Nutrition to help control hunger and satiety giving you four to five hours of appetite suppression. The balance of protein to low-glycemic carbohydrates helps control hormones in the gut, brain, and the blood*. This is the foundation of the Zone Diet and is enhanced by the presence of prebiotics and polyphenols.

If you want optimal wellness, you need a lifetime strategy and products that deliver results you can see, feel and test.  The ZoneRx shakes are part of that dietary strategy. We call it Evidence-based Wellness®.

Serving Suggestions

To promote an even better gut health response, we suggest mixing 1 scoop of ZoneRx Shake mix with 10 ounces of 2% lactose-free milk in place of water and adding 1 Zone block of berries (about 1 cup). Lactose free milk provides complex sugars not found in plant sources that promote an even greater gut health response by supporting the growth of friendly bacteria while maintaining the balance of protein and low-glycemic carbohydrates needed for maximum Controlled Release Nutrition. The absence of lactose in the product will eliminate any digestive problems for individuals with even the slightest amount of lactose intolerance. The use of berries gives the ZoneRx Shakes even better glycemic control and gut health benefits with the polyphenols and fiber they contain.

10 Servings Per Container

5/5 (1 Review)

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  • Science
  • Ingredients
  • Reviews (7)
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Appetite suppression requires both stable blood sugar control and a healthy gut to be working in unison. Our new ZoneRx shakes do both with their combination of a balanced protein to low glycemic carbohydrate ratio plus the inclusion of 250mg of highly-purified polyphenol extracts needed for optimal gut health.

How ZoneRx Shakes work…

Our Controlled Release NutritionÒ technology helps support stable blood sugar levels with the balance of protein to the glycemic load in each food product we produce. That basic concept of Controlled Release Nutrition is now enhanced with high levels of purified polyphenol extracts to promote optimal gut health (1,2) *. Now you have a 1-2 punch for hours of appetite control with unrivaled taste and convenience. If you aren’t hungry, you eat fewer calories. If you eat fewer calories, you lose excess body fat. If you lose excess body fat, your blood pressure, blood sugar, and blood lipids will improve. It’s that easy when you are in the Zone.  The ZoneRx shakes make it easier to get there.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease

  1. Sears B and Ricordi C. “Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome, and diabetes.”  Eur Rev Med Pharmacol Sci 16:1137-1154 (2012)
  2. Sears B. “Polyphenols: Novel applications in human health.”  CellR4 5:e2437 (2017)



7 reviews for Dr. Sears’ ZoneRx Shakes – Vanilla (10 servings)

  1. Denny Warren

    The taste is excellent I have Vanilla and chocolate they blend well in blender or the shaker.
    The best tasting of any shake I have tried. Adding a little sugar free ice cream and fruit makes it a meal in itself. I have been using Zone products for several years now close to 20 years. I am never disappointed from the time I order to the time I use the product..I have used the 0-3 for a better part of 20 years would be lost without it.

  2. JD

    Good fast source of protein. My son likes the strawberry and I like the chocolate. Doesn’t have the chalky taste that protein shakes Sometimes do. I do have a question though, is this product NSF certified for sport? Thanks

    • Dr. Sears Zone

      JD, Thank you for your comment and question. At this time, the ZoneRx shakes are not NSF certified for sport. Thank You, Dr. Sears’ Zone

  3. Martha W.

    I’ve tried both the strawberry and vanilla shakes and love them both. My grandchildren love them also. Good work!

  4. MARIE PALUMBO (verified owner)

    I just received my ZoneRX shakes today…I was wondering if I can use almond or coconut milk and get the same results as the 2% lactose free milk?

    • Zone Customer Support

      Marie, Thank you for your question. If you choose to use a dairy alternative Dr. Sears recommends utilizing 10 oz. of Unsweetened Almond Milk to replace the 2% Lactose Free Milk and include 1 oz. or 22 Almonds on the side to replace the missing protein from the milk. Another option (if you do not have extra almonds handy) would be to utilize 1 ½ scoops of the shake powder rather than just 1 scoop to provide the additional protein. Thank You, Dr. Sears’ Zone Customer Support

  5. Nancy (verified owner)

    I purchased the chocolate and vanilla meal replacements. The chocolate is exceptional. Just tried the vanilla and it is very good. The mauve colour put me off for a bit but the flavour is very good. Chocolate is my favourite but vanilla makes a nice change. Love the products

  6. Lori Preshaw

    I have not tried any products. Can’t find what the protein sources are in bars or shakes. Or what type of sugars.

    • Zone Labs Customer Support

      Lori, Thank you for your question. As you can see in the ingredients panel, the Shakes utilize a protein blend of Whey Protein Isolates and Milk Protein Isolates. For sugars, Dr. Sears utilizes fructose which is essentially fruit sugar and has a lower glycemic load than other sugars to help keep insulin levels stabilized. We sure hope this helps you out in making your purchase decision. Thank You, Zone Customer Support

  7. Ron Dunchok (verified owner)

    I’ve been using Dr Sears fish oil for more than 10 years and am looking to lose a little weight
    I have tried meal replacement protein shakes from the health food store and the gym but without success. Mainly they had a funny aftertaste, I wasn’t full and I felt bloated!
    I’m afraid I’ll sound like a paid endorser but I really like the Zone shakes. Ive been using them for one week now and I am not experiencing the taste or gi symptoms I was having before! No heartburn belching ,bloating nor is there the “funny” aftertaste. They keep me sated longer. The weight loss verdict is still to be determined!
    My one complaint is the price is a bit high!

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Why Do ZoneRx Shakes Look Purple?

The purple color, most notable in the vanilla shakes comes from the presence of the highly purified polyphenol extract derived from the maqui berry. Maqui berry contains the highest levels of a special class of polyphenols known as delphinidins.  These are the same polyphenols that give red wine its color.

I’m not lactose intolerant do I still need to use lactose-free milk?

We suggest using 10oz of 2% lactose-free milk in place of water or milk alternatives even if you don’t have issues with lactose.  Many individuals may have a low-level sensitivity to lactose even if they aren’t lactose intolerant, so the complete removal of lactose can only help to improve gut health (1).

Lactose-free milk is rich in complex sugars similar to those found in human breast milk.  These complex sugars are not found in plant sources and thus provide the ideal nutrition to generate more beneficial species of bacteria in our gut.

  1. Grand RJ, Montgomery RK, Chitkara DK, and Hirschhorn JN. Changing genes; losing lactase gut 52: 617–619 (2003)

Is the ZoneRx Shake Mix Lactose-Free?

Yes, the ZoneRx Shake mix is lactose-free.  The lactose found in standard whey and milk protein sources has been totally removed by ultrafiltration.  These are known as isolates because of the removal of lactose.  This is a complex process, but essential for optimal gut health.

If you use the ZoneRx Shakes, do you still need to supplement with polyphenols?

Dr. Sears believes that individuals should consume at least 1,000 mg of polyphenols per day for wellness and athletic performance and about 1,500 mg per day for anti-aging to help with stimulation of AMP kinase*.  To get those levels, one would need to eat about 10 servings of non-starchy vegetables and fruits. Reaching those levels with food alone is difficult.  Furthermore, many of the sources rich in polyphenols either have pesticide contamination or heavy metal contamination.  For example, strawberries and spinach are good sources of polyphenols, but each is often rich in pesticides.  Cocoa powder which is the basic component of chocolate products is often rich in the heavy metal cadmium.  The polyphenols we use in the ZoneRx shakes are highly purified polyphenol extracts that have GRAS status meaning they have passed strict testing to be able to be used in food products.  Virtually no other polyphenol extract available has this designation.  Although we are the only company to list the levels of polyphenols in all of our polyphenol-enriched products, it is the type of polyphenols in those products that makes a difference.  The polyphenol extracts used in the ZoneRx Shakes is a combination of a chromatographically purified Maqui berry extract, rich in delphinidins to help support improved blood sugar control, and cadmium-free cocoa extracts that help support improved blood flow and reduction of insulin resistance.  Both of these polyphenol extracts have been supported by clinical studies (1).

  1. Sears B. “Polyphenols: Novel applications in human health.”  CellR4 5:e2437 (2017)

Are ZoneRx Shakes Gluten Free?

Yes, the ZoneRx shakes are gluten-free.  Unless someone has true celiac disease, gluten should not be a concern as Dr. Sears and vast majority of the gut research community believes that individuals who are “gluten sensitive” may actually have sensitivity to FODMAPs (Fermentable Oligo-, Di- and Monosaccharides And Polyols (1).

  1. Muir JG and Gibson PR. The Low FODMAP Diet for Treatment of Irritable Bowel Syndrome and Other Gastrointestinal Disorders. Gastroenterol Hepatol 9: 450–452 (2013)

Are ZoneRx Shakes non-GMO?

Yes, the ZoneRx shakes are non-GMO.

What Allergens do the ZoneRx Shakes include?

The ZoneRx shakes do contain milk and soy. These come from the milk fractions that supply the protein and the soy lecithin used as an emulsifier in ZoneRx Shake.  The whey protein isolate and milk protein isolate used the ZoneRx Shake are both lactose-free.  They are more expensive, but provide a far better quality of both proteins with significantly less potential effects on gut health since lactose-free products also low in FODMAPs.

What are the sources of prebiotics in ZoneRx?

Prebiotics are the fermentable fibers essential for gut health.  The sources of prebiotics in ZoneRx come from a variety of natural fermentable fibers including guar gum, inulin, oat fiber, fructo-oligo saccharides, and a synthetic resistant starch (Fiber-Sol).  These fermentable fibers are required to supply the necessary energy and metabolites (such as short chain fatty acids) for maintenance of gut barrier integrity to help prevent a leaky gut*.  However, without adequate levels of polyphenols present at the same time, optimal gut health will not be achieved.

Does the cocoa in ZoneRx contain caffeine?

The cocoa extract used in ZoneRx Shakes is a highly purified to reduce heavy metals, such as cadmium, while simultaneously increasing its polyphenol content.   There is some caffeine in the cocoa polyphenol extract, but in very low concentrations, and when this is diluted in the final shake it represents far less caffeine than found in a cup of decaffeinated coffee.

Are ZoneRx Shakes suitable for children?

ZoneRx Shakes are ideal for children as they are balanced in protein and carbohydrate, plus they contain both polyphenols and fermentable fiber (i.e. prebiotics) that promote a healthy gut. We might suggest using ½ a scoop and 5oz of lactose-free milk for small children because of their smaller size.

Do ZoneRx Shakes contain artificial sweeteners?

No. Artificial sweeteners can cause adverse changes in the microbial composition of the gut. The only sweeteners used in ZoneRx Shake are natural sweeteners such as allulose, monk fruit and stevia.

What is allulose and why did it replace fructose as the primary sweetener in the ZoneRx Shakes?

Allulose is a natural low-calorie sweetener that has a similar sweet taste to real sugar. Allulose has the same chemical formula as fructose, but it is arranged differently. Why we prefer it to fructose is that this difference in structure prevents your body from metabolizing allulose the same way as fructose, making it a low-calorie sweetener that provides more health benefits. This further improves the hormonal and appetite control of the ZoneRx Shakes to make them an even more ideal meal replacement.

Why do you include soy in the shakes?

Zone shakes contain soy lecithin which is exceptionally low in isoflavones and used as an emulsifier to help with texture and creaminess.