Zone Labs Cellular Inflammation Test Kit

Price: $75.00

(68 customer reviews)

If your level of cellular inflammation is high, the body begins attacking itself. If it is too low, then your body can’t fight off microbial invaders effectively. You need to keep the body’s level of cellular inflammation in a zone. Elevated levels of cellular inflammation are the underlying cause of why we gain weight, develop chronic disease, and age at a faster rate.

This simple finger-stick blood test measures the levels of two key fatty acids in the blood, Arachidonic Acid (AA) an omega-6 fatty acid and Eicosapentaenoic Acid (EPA), an omega-3 fatty acid. The average American has a score of approximately 20 but to be considered well Dr. Barry Sears recommends you be between 1.5 and 3. Don’t guess about cellular inflammation. Taking a painless fingertip blood test is the only way to know if you have high levels of cellular inflammation.

How it works:



  • Test available in U.S. and internationally. However, New York state law prohibits the distribution of blood testing kits from Zone Labs. Therefore we are unable to process Internet orders from customers in New York at this time.
  • Due to safety standards associated with medical products, the Zone Labs Cellular Inflammation Test Kit is exempt from our  30-day return policy.


3.4/5 (47 Reviews)

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  • Reviews (68)

Cellular Inflammation Testing

Measuring Your Future Wellness

We all desire to have a clinical marker of our future state of wellness. It is my opinion that the AA/EPA ratio in the blood is the best marker of that elusive goal because it measures the level of cellular inflammation in the body.

What is Cellular Inflammation?

Cellular inflammation is the type of inflammation that is below the perception of pain. What it does is disrupt hormonal signaling at the cellular levels that leads to increased fat accumulation, acceleration of the development of chronic disease, and decreased physical performance. You can’t feel cellular inflammation, but you can measure it. The only way to measure cellular inflammation is by testing the ratio of two essential fatty acids (AA and EPA) in your blood.

What is the AA/EPA Ratio?

The AA/EPA ratio is an indication of the levels of cellular inflammation in your body. High levels of cellular inflammation does not mean you have a disease state, but it does indicate that you are not as well as you could be. Your future state of wellness can be determined by the levels of cellular inflammation in the blood as shown below.


AA/EPA Ranges Cellular Inflammation Future state of wellness
1.5 to 3 Low Excellent
3 to 6 Moderate Good
7 to 15 Elevated Moderate
> than 15 High Poor


The higher your levels of cellular inflammation, the more likely the future development of chronic disease will be accelerated. A recent study from Italy has demonstrated that the AA/EPA ratio is always greater than 15 in patients with chronic diseases (1).

Dietary Methods to Improve the AA/EPA Ratio

There are no drugs that can change the AA/EPA ratio. This is because the AA/EPA ratio is a consequence of the diet. One method of lowering the AA/EPA ratio is to increase the intake of high-purity omega-3 fatty acid concentrates rich in EPA. This will increase the EPA content in the blood (2). This represents the fastest way to reduce the AA/EPA ratio. However, the best long-term method is to reduce the AA levels in the blood. This is best achieved by following a strict anti-inflammatory diet, such as the Zone Diet (3-5). The Zone diet was designed to reduce elevated levels of both insulin and omega-6 fatty acids so that the production of AA is significantly reduced. The combination of an anti-inflammatory diet coupled with high-purity omega-3 concentrations represents the most powerful dietary approach to reach and maintain a low level of cellular inflammation for a lifetime.

How much EPA and DHA do I have to take to reduce the AA/EPA ratio?

A recent dose-response study in healthy women who had a high risk for potential breast cancer has provided supplementation guidelines for reduction of the AA/EPA ratio (5).


Grams of EPA and DHA supplemented per day AA/EPA Ratio
0 12.1
0.8 4.7
2.5 2.6
5.0 1.3
7.5 1.2


This data indicates that a daily dosage of EPA and DHA of 2.5 grams was sufficient to bring the AA/EPA ratio into the desired range for excellent wellness for these healthy individuals. This level of EPA and DHA recommendation correlates well with an Italian study that demonstrated in patients with various chronic diseases having an elevated AA/EPA ratio (>15) lowered their elevated AA/EPA ratio to approximately 5 with daily supplementation of 2.5 grams of EPA and DHA (1). This is also indicative that a person with an existing chronic disease may need greater amounts of EPA and DHA to get them into an excellent wellness range compared to a healthy individual.

However, these are only general guidelines for daily EPA and DHA supplementation. The best indication of the amount of EPA and DHA required to optimize the AA/EPA ratio for an individual is best determined with blood testing every six to twelve months.

The benefits of reduction of the AA/EPA ratio.

The JELIS study was one of the largest cardiovascular studies ever done using more than 18,000 subjects with elevated cholesterol levels. When these subjects were given high doses of EPA (1.8 grams of EPA per day), their average AA/EPA ratio decreased from 1.6 to 0.8. This reduction in the AA/EPA ratio was associated with an additional 19% reduction in cardiovascular events during the next four and half years (7).

Until there is more data, I do not believe it prudent to reduce the AA/EPA ratio to less than 1.5 even through significant cardiovascular benefits do occur at lower AA/EPA ratios in patients with elevated cholesterol levels as demonstrated in the JELIS study.


  1. Rizzo AM, Montorfano G, Negroni M, Adorni L, Berselli P, Corsetto P, Wahle K, and Berra B. “A rapid method for determining arachidonic:eicosapentaenoic acid ratios in whole blood lipids: correlation with erythrocyte membrane ratios and validation in a large Italian population of various ages and pathologies.” Lipids in Health and Disease 9:7 (2010)
  2. Sears B. The OmegaRx Zone. Regan Books. New York, NY (2002)
  3. Sears B. The Zone. Regan Books. New York, NY (1995)
  4. Sears B. The Anti-Inflammation Zone. Regan Books. New York, NY (2005)
  5. Sears B. Toxic Fat. Thomas Nelson. Nashville, TN (2008)
  6. Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, and Clinton SK. “Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition.” Am J Clin Nutr 91: 1185-1194 (2010)
  7. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, and Shirato K. “Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.” Lancet 369: 1090-1098 (2007)

68 reviews for Zone Labs Cellular Inflammation Test Kit

  1. Delia D. (verified owner)

    An easy test to perform, painless and efficiently designed from top to bottom. This test is not part of the annual physical examination that is covered by many medical insurances, so I strongly recommend it. Inflammation is a major risk to our health, do not hesitate to take advantage of this test!

  2. Lawrence W

    I really like this test. I’ve purchased it for myself, and for 4 others with chronic diseases that should benefit from the Zone Diet and Zone Supplements.

  3. Steve Paselk (verified owner)

    Zone Labs needs to review their shipping methods to Hawaii and Alaska. USPS is the fasted
    cheapest and most reliable taking 4-7 days max for first class. Using Fed Ex at a higher cost
    it is expected to take 25 days to arrive taking 8-9days to drive it from east coast to west coast then it is turned over to the post office at the cheapest package rate to be sent by barge-thus the 25 day expected arrival time. Had this been a critical medical test I would have been very
    upset. My mail address in Hawaii is a PO Box.

  4. Kristen F.

    I agree with you all! I just received this year’s test kit and I’m so excited to eventually receive the results – and compare them with previous years. This is a fabulous perk of being an Advantage member, for which I am most grateful! What does intrigue me however would be the longevity data. I can’t imagine it would be too difficult to get. The point is, I’ve got a lot left I want do, including start my career over like five times, etc…and I’m already 47 so I’m really hoping this is the case (that the two are in fact correlated). 🙂

  5. Simon Berti

    Very good experience. There was a problem with delivery that you resolved very prompt and free of charge.

  6. Michael Williams (verified owner)

    Test was easy to complete and submit. The instructions are concise and easy to follow. I received my results sooner than expected.

  7. Gordon Wanless (verified owner)


  8. Marco

    Can I use the test several time or is a one time only test? thank you

  9. Pamela M. (verified owner)

    When I first discovered Dr. Sear’s book, Two weeks in The Zone, there was no test to determine one’s degree of inflammation. When I started developing osteoarthritis in my right thumb I knew I had to revisit the Zone and was so glad to find the Zone kit to test my blood. I’ve now got the results and have taken steps to reverse the direction of damage that’s been happening sense the last time I tried the Zone.

  10. Gloria Maestas (verified owner)

    Test arrived quickly and. Ery easy to use. Results also came sooner than expected.

  11. diego guayara

    edad 48 años actividad fisica 5 dias a la semana 20 de cardio y 25 de fuerza, rinitis alergica , no otras patologias asociadas talla 1.67 ,mts , peso 65 kg,% grasa 16

  12. diego guayara

    edad 48 años actividad fisica 5 dias a la semana 20 de cardio y 20 de fuerza , rinitis alergica . no otras patologias asociadas

  13. L. Waters

    Ordered test for my wife to 1) establish a starting baseline, and 2) convince her to start taking your fish oil to help her planned standard medical treatment for a recently discovered condition. The dose is the same low one I take (3g/day), but I wanted to get her started on fish oil. Depending on the results of surgery next week, I may request another blood test kit in a few weeks to see if her current low dose of fish oil has reduced her AA/EPA ratio. She has a considerable level stored AA to overcome.

  14. Virginia Engler (verified owner)

    I do this once a year to make sure my cellular inflammation is where it should be. So far, so good. I am 1.7 which is excellent. Thanks, Dr. Sears.

  15. mitchell (verified owner)

    I don’t have the results

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