Zone Labs Cellular Inflammation Test Kit

Price: $75.00

(67 customer reviews)

If your level of cellular inflammation is high, the body begins attacking itself. If it is too low, then your body can’t fight off microbial invaders effectively. You need to keep the body’s level of cellular inflammation in a zone. Elevated levels of cellular inflammation are the underlying cause of why we gain weight, develop chronic disease, and age at a faster rate.

This simple finger-stick blood test measures the levels of two key fatty acids in the blood, Arachidonic Acid (AA) an omega-6 fatty acid and Eicosapentaenoic Acid (EPA), an omega-3 fatty acid. The average American has a score of approximately 20 but to be considered well Dr. Barry Sears recommends you be between 1.5 and 3. Don’t guess about cellular inflammation. Taking a painless fingertip blood test is the only way to know if you have high levels of cellular inflammation.

How it works:



  • Test available in U.S. and internationally. However, New York state law prohibits the distribution of blood testing kits from Zone Labs. Therefore we are unable to process Internet orders from customers in New York at this time.
  • Due to safety standards associated with medical products, the Zone Labs Cellular Inflammation Test Kit is exempt from our  30-day return policy.
4/5 (4 Reviews)

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Cellular Inflammation Testing

Measuring Your Future Wellness

We all desire to have a clinical marker of our future state of wellness. It is my opinion that the AA/EPA ratio in the blood is the best marker of that elusive goal because it measures the level of cellular inflammation in the body.

What is Cellular Inflammation?

Cellular inflammation is the type of inflammation that is below the perception of pain. What it does is disrupt hormonal signaling at the cellular levels that leads to increased fat accumulation, acceleration of the development of chronic disease, and decreased physical performance. You can’t feel cellular inflammation, but you can measure it. The only way to measure cellular inflammation is by testing the ratio of two essential fatty acids (AA and EPA) in your blood.

What is the AA/EPA Ratio?

The AA/EPA ratio is an indication of the levels of cellular inflammation in your body. High levels of cellular inflammation does not mean you have a disease state, but it does indicate that you are not as well as you could be. Your future state of wellness can be determined by the levels of cellular inflammation in the blood as shown below.


AA/EPA Ranges Cellular Inflammation Future state of wellness
1.5 to 3 Low Excellent
3 to 6 Moderate Good
7 to 15 Elevated Moderate
> than 15 High Poor


The higher your levels of cellular inflammation, the more likely the future development of chronic disease will be accelerated. A recent study from Italy has demonstrated that the AA/EPA ratio is always greater than 15 in patients with chronic diseases (1).

Dietary Methods to Improve the AA/EPA Ratio

There are no drugs that can change the AA/EPA ratio. This is because the AA/EPA ratio is a consequence of the diet. One method of lowering the AA/EPA ratio is to increase the intake of high-purity omega-3 fatty acid concentrates rich in EPA. This will increase the EPA content in the blood (2). This represents the fastest way to reduce the AA/EPA ratio. However, the best long-term method is to reduce the AA levels in the blood. This is best achieved by following a strict anti-inflammatory diet, such as the Zone Diet (3-5). The Zone diet was designed to reduce elevated levels of both insulin and omega-6 fatty acids so that the production of AA is significantly reduced. The combination of an anti-inflammatory diet coupled with high-purity omega-3 concentrations represents the most powerful dietary approach to reach and maintain a low level of cellular inflammation for a lifetime.

How much EPA and DHA do I have to take to reduce the AA/EPA ratio?

A recent dose-response study in healthy women who had a high risk for potential breast cancer has provided supplementation guidelines for reduction of the AA/EPA ratio (5).


Grams of EPA and DHA supplemented per day AA/EPA Ratio
0 12.1
0.8 4.7
2.5 2.6
5.0 1.3
7.5 1.2


This data indicates that a daily dosage of EPA and DHA of 2.5 grams was sufficient to bring the AA/EPA ratio into the desired range for excellent wellness for these healthy individuals. This level of EPA and DHA recommendation correlates well with an Italian study that demonstrated in patients with various chronic diseases having an elevated AA/EPA ratio (>15) lowered their elevated AA/EPA ratio to approximately 5 with daily supplementation of 2.5 grams of EPA and DHA (1). This is also indicative that a person with an existing chronic disease may need greater amounts of EPA and DHA to get them into an excellent wellness range compared to a healthy individual.

However, these are only general guidelines for daily EPA and DHA supplementation. The best indication of the amount of EPA and DHA required to optimize the AA/EPA ratio for an individual is best determined with blood testing every six to twelve months.

The benefits of reduction of the AA/EPA ratio.

The JELIS study was one of the largest cardiovascular studies ever done using more than 18,000 subjects with elevated cholesterol levels. When these subjects were given high doses of EPA (1.8 grams of EPA per day), their average AA/EPA ratio decreased from 1.6 to 0.8. This reduction in the AA/EPA ratio was associated with an additional 19% reduction in cardiovascular events during the next four and half years (7).

Until there is more data, I do not believe it prudent to reduce the AA/EPA ratio to less than 1.5 even through significant cardiovascular benefits do occur at lower AA/EPA ratios in patients with elevated cholesterol levels as demonstrated in the JELIS study.


  1. Rizzo AM, Montorfano G, Negroni M, Adorni L, Berselli P, Corsetto P, Wahle K, and Berra B. “A rapid method for determining arachidonic:eicosapentaenoic acid ratios in whole blood lipids: correlation with erythrocyte membrane ratios and validation in a large Italian population of various ages and pathologies.” Lipids in Health and Disease 9:7 (2010)
  2. Sears B. The OmegaRx Zone. Regan Books. New York, NY (2002)
  3. Sears B. The Zone. Regan Books. New York, NY (1995)
  4. Sears B. The Anti-Inflammation Zone. Regan Books. New York, NY (2005)
  5. Sears B. Toxic Fat. Thomas Nelson. Nashville, TN (2008)
  6. Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, and Clinton SK. “Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition.” Am J Clin Nutr 91: 1185-1194 (2010)
  7. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, and Shirato K. “Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.” Lancet 369: 1090-1098 (2007)

67 reviews for Zone Labs Cellular Inflammation Test Kit

  1. Christina W. (verified owner)

    This blood test is super easy to get a great look at what inflammation you have going on in your body. Even though you may feel just fine you have no idea what is going on inside. This test is easy and you get the results quickly. The report is very detailed so you know exactly what is going on and then you can correct it and re test again down the road and see the improvement.

  2. fam 4th (verified owner)

    Found the process of ordering and delivery easy and as stated. Liked the result as I did last year..(under 2). Was a little confused though about the fact I’m scoring well since I have osteoarthritis in my hands and feet. Was left questioning a little about the test and its efficacy..still ordering another test though for my 50 year old son!

  3. Ed Scherrer (verified owner)

    I too had difficulty producing much of a blood sample though it was, apparently, enough as the results were returned promptly. AA 4.5%, EPA 6.1% and the ratio 0.7. I have been consuming about 12 to 15 servings per day of vegetables, heavily tilted to the cruciferous veggies. I eat a moderate amount of protein at each meal. Very few starches and sugars and usually don’t bother with fruits at all. I have been taking 5.6 grams of fish oil per day that contain 3.9 grams of EPA/DHA combined. Haven’t had a phone consultation yet though I expect to cut back to 4.2 grams of fish oil

  4. Phil

    Test kit need lancets which go deeper, I had to
    “wring out” my finger to get enough blood
    to cover about 1/4th of the circular test area.
    I was recommended to fill the test area.
    Had a AA/EPA =1.4, so I need to cut back on
    my fish oil and EVOO amounts..

  5. Marilyn Welker

    Excellent service from start to finish, along with a most useful test. Thank you!

  6. J. Taylor (verified owner)

    Took the blood test on 1-31-17 with the results being just outside the Japanese range on two capsules a day, one in the morning & one later in the afternoon. Eating wild Alaska salmon, sardines & colorful vegetables for 2 weeks prior to the test also helps.

  7. John Andrews

    My wife made me take it. I am OK, not to high, in the Good range. My wife is happy.

  8. Susan (verified owner)

    Kit arrived promptly. The test was quick and easy with a few pricks. I sent it off and the results came back within 2 weeks. I was in a good range but needed a little less inflammation. I was taking a teaspoon a day, so I upped it to 2 teaspoons every other day. I’ll test again in a few months. I love blood tests because they tell so much!

  9. Ashok G Patel MD (verified owner)

    I have been proponent of OmegaRx ever since the Zone OmegaRx Dr Barry Sears one of many books was out 2001. I am family practice MD and I have been recommending supplement to my patients and OmegaRx has been my number one. I used to test my patients for Silent Inflammation profile sending blood samples to Canada. Now with the ZoneLabs kit it is very simple and I ordered my kit and within ten days max I received my results on target range. I will now be able to convince patients to do this test. I think everyone should know their Silent Inflammation Profile and get to target range with help of Ultra refined OmegaRx2

  10. Rosy Villarreal (verified owner)

    All the people need this blood test.

  11. Lazaros

    The kid works in Europe? I live in Cyprus (an island in eastern Mediterranean). Can I ordered it?

  12. Wayne Walker (verified owner)

    The kit arrived promptly, as did the results. I took advantage of the phone consultation. This was helpful because it called my attention to the EPA/DHA ratio of the current Omega 3 tablets that I have been taking. They were higher in DHA and lower in EPA than Dr. Sears recommends. As a result, I am changing to the Zone Omega 3 Fish Oil.

    Wayne Walker

  13. Tyler Sue (verified owner)

    Best test ever!! I will be sending many clients!! Best thing to know, is if what you’re trying to change, is working! I’m a holistic health coach ?

  14. Phil Barry (verified owner)

    We ordered 2 tests & returned them on the same day. Results of 1 have been reported & my wife is delighted that she is perfect (I already knew that). My results have not yet been received.

  15. Winona Walton (verified owner)

    Easy to use and quick results.

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