What Are Omega-3s and How Do They Work?

Omega-3s are the building blocks for hormones that help combat or resolve inflammation. When we have too much inflammation it is one of the main reasons we gain weight, develop chronic disease, and age at a faster pace. A diet rich in omega-3s (e.g. fish and fish oil) can help minimize inflammation, whereas a diet rich in omega-6 fats (e.g. corn oil, soybean oil, safflower oil) can promote inflammation. The problem is that most Americans have a diet incredibly low in omega-3s and incredibly rich in omega-6 fats.

Studies have shown that the rise in our obesity epidemic parallels our increased intake of omega-6s and decreased intake of omega-3s. This is why it’s important to have the appropriate balance of both to minimize inflammation and promote overall wellness.

Health Benefits of Omega-3s

There are numerous benefits that come from having a diet rich in omega-3s and low in omega-6s like the following:

Heart Health

Heart Health

Brain Health

Brain Health

Behavior and Mood

Behavior and Mood

Athletic Performance

Athletic Performance



Pre/Postnatal Health

Pre/Postnatal Health

Chart comparing the amount of Eicosapentaenoic Acid and Docosahexaenoic Acid in DR Sears OmegaRX 2 vs. other fish oil sources

Which Omega-3s Are Important for Health?

The primary benefits of omega-3s come from their ability to resolve inflammation. There two omega-3s that have been most widely studied for their clinical benefits pertaining to decreased inflammation are EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid).

  • EPA and DHA are found primarily in fish and fish oil.
  • EPA helps minimize the formation of hormones known to promote inflammation (i.e. eicosanoids) while both EPA and DHA help generate hormones critical to resolving inflammation (i.e. resolvins).
  • A 2:1 ratio of EPA to DHA has been shown in the scientific literate to cover the widest range of health benefits.

Why Omega-3 Fish Oil is Superior to Krill Oil, Flaxseed or Other Omega-3 Products

Dr. Sears recommends individuals consume a minimum of 3000 mg of EPA and DHA daily for wellness. In order to reach Dr. Sears’ recommended intake you need purified omega-3 fish oil rather than consuming fish alone, but you need to choose wisely.

  • Krill oil is actually made of crustaceans (small shrimp) that have been harvested and extracted using harsh chemicals (hexane and acetone).
  • Flaxseed, a vegetarian source of the omega-3 alphalinolenic acid (ALA), is only beneficial if it’s converted into EPA and DHA.
  • The conversion of ALA into EPA and DHA is very inefficient (about 1-10%) so you would have to consume large quantities to get the same benefits of a much smaller amount of omega-3 fish oil rich in EPA and DHA.

EM (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid)

What Makes OmegaRx 2 Different?


All fish oil products use the same raw material (sardines and anchovies), but what separates one from the other is their purification. PCBs, or polychlorinated biphenyls, are the most difficult toxins to remove from fish oil. Dr. Sears’ standards for PCBs are 25 times more stringent than pharmaceutical standards and 45 times more rigid than those established for the dietary supplement industry.


It is the total amount of EPA and DHA that deliver the health benefits of omega-3s. OmegaRx 2 supplies 750mg of EPA and DHA per gram (1 capsule) of fish oil. This is among the highest amounts of EPA and DHA currently offered in the market place without a prescription. Each serving of OmegaRx 2 (4 capsules or 1 tsp) supplies 3000mg of EPA and DHA.


When you purchase an omega-3 fatty acid product it’s important to look at the cost per gram of EPA and DHA in the product. OmegaRx 2 has one of the lowest cost per gram of EPA and DHA of any fish oil product on the market coupled with the highest purity standards for freshness.


We think it’s important that you know the purity, potency and freshness of OmegaRx 2 which is why we post the values of these for every lot of OmegaRx 2 on our website. Where other companies don’t post their results or will post those of their raw materials versus finished products, we post the results of our products post-production on every batch.


Dr. Sears has dedicated more than 40 years of research on the impact of diet and omega-3s on inflammation and hormonal response. His scientific contributions have helped lead the omega-3 industry in the manufacturing, purification, and stabilization of high potency and purity omega-3 products.

Omega 3 Fish Oil Capsules

Which is Right For You?

Determine which OmegaRx 2 best fits your needs.

Dr. Sears Zone OmegaRx2, 120 capsules

OmegaRx 2

Ideal for: general wellness — our most popular Omega-3 product.

OmegaRx 2 Fish Oil, 10oz liquid - get your omega-3s

OmegaRx 2 — Liquid

Ideal for: those who have difficulty swallowing capsules.

Dr. Sears Zone OmegaRx2 Sport, 120 capsules

OmegaRx 2 Sport

Ideal for: those who exercise more than 1 hour per day with intensity.

Dr. Sears Zone OmegaRx2, 240 micro-capsules

OmegaRx 2 — Micro Capsules

Ideal for: those who have difficulty swallowing larger capsules.

Zone Labs AA/EPA Ratio Blood Test Kit

Cellular Inflammation Test Kit

Ideal for: determining the amount of omega-3s you need

Zone Fish Oil Shot Glass

Fish Oil Shot Glass

Ideal for: measuring and consuming liquid OmegaRx 2.

Want to learn more?

If you are interested in learning more about Omega-3s, the following links will help you:


Explore the real difference in this Dr. Sears blog

Read More

Omega-3 Q&A

Dr. Sears answers the top questions we receive

Read More

Purity Reports

We test every lot of OmegaRx 2 and post the results for complete transparency

Learn More

Dr. Sears Blog

Check out his latest articles on various health topics and supplementation

Read More

Omega-3s and The Pro-Resolution Nutrition System

As powerful as OmegaRx 2 is, it is only one of the steps toward getting you in the Zone. To reach the Zone and stay there, you need to follow the Zone Pro-Resolution Nutrition system consisting of the Zone Diet to reduce diet-induced inflammation, adequate levels of omega-3 fatty acids to resolve residual diet-induced inflammation, and adequate levels of polyphenols to activate the genes that are required to repair the tissue damage caused by diet-induced inflammation.