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Doctor Barry Sears

Dr. Sears Comments:

Even though the symptoms of heart attack in women are different than men, the underlying cause is the same:  Increased cellular inflammation.  The primary solution to heart disease is not reducing cholesterol but reducing inflammation.
Doctor Barry Sears

Dr. Sears Comments:

Here's a better recommendation:  Reduce inflammation in the arterial wall that causes the rupture of soft vulnerable plaques.  That will do more for you than taking a walk.
Doctor Barry Sears

Dr. Sears Comments:

As pointed out in the article, exercise increases dopamine as does high-dose fish oil. Perhaps putting physical education programs back in schools, eliminating driving kids to school instead of having them walk to school and taking their fish oil before leaving for school may be a better, low-cost solution to ADHD than increased drugs and special- education classes.
Doctor Barry Sears

Dr. Sears Comments:

The only way to treat a leaky gut is an anti-inflammatory diet coupled with high-dose omega-3 fatty acids and polyphenols to help alter the microbial composition in the gut. 
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately, the article failed to mention one natural treatment (and I didn't know that electro-convulsive shock therapy is a natural treatment) is high-dose fish oil, especially since it has been proven to be clinically effective.
Doctor Barry Sears

Dr. Sears Comments:

Besides a lot of rest, the child also needs a lot of fish oil to reduce the neuroinflammation in the brain.
Doctor Barry Sears

Dr. Sears Comments:

Two of the primary causes of cataracts are trauma and radiation. Both generate inflammation.  Polyphenols and omega-3 fatty acids are much more powerful anti-inflammatory agents than vitamin E and selenium.
Doctor Barry Sears

Dr. Sears Comments:

The published data are clear that even high-dose fish oil doesn't cause increased bleeding if the AA/EPA ratio remains above 1.  Relative to the declining rate of CHD mortality in the last 30 years, give the credit to reduced smoking, not increased statins.
Doctor Barry Sears

Dr. Sears Comments:

This may be another reason why high-dose fish oil demonstrates significant improvements in children with ADHD.  The DHA can speed up neurogenesis and the EPA can reduce inflammation.  The combination would improve the speed and quality of new brain connections.
Doctor Barry Sears

Dr. Sears Comments:

Not only are farmed salmon fatter than wild salmon, but they contain a lot more PCBs.
Doctor Barry Sears

Dr. Sears Comments:

A simple blood test like the AA/EPA ratio can also help diagnose children.  If the ratio is high, then the first "drug" to use is high-dose fish oil before thinking about traditional drugs.
Doctor Barry Sears

Dr. Sears Comments:

They are if they are given at a placebo dose.  The same is true for drugs.  Using a meta-analysis for science is also a waste of research money.  Usually you take a number of poorly designed trials (especially those using omega-3 fatty acids) using a placebo-like dose and then grind them up like sausages.  Bad-quality meat makes bad-quality sausage.  The same is true in clinical research.
Doctor Barry Sears

Dr. Sears Comments:

That's great, but you need a better treatment.  That treatment is high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Very striking evidence that serotonin may be the cause of depression.  A more likely candidate is inflammation disrupting the communication of neurotransmitters into the interior of the neuron.  This is why high-dose fish oil is effective in treating depression.
Doctor Barry Sears

Dr. Sears Comments:

It is still clear that in women statin use increases diabetes incidence. A better alternative is an anti-inflammatory diet to reduce insulin levels that cause the excess production of cholesterol in the liver in the first place.
Doctor Barry Sears

Dr. Sears Comments:

Excellent point on olive oil and fish oil vs. saturated fats that is found in the correction to the widely quoted article that led to the media report that saturated fats are good. The data demonstrate that saturated fats cause inflammation, whereas olive oil and fish oil have more anti-inflammatory fats.
Doctor Barry Sears

Dr. Sears Comments:

I would call their "high-dose" barely beyond a placebo dose.
Doctor Barry Sears

Dr. Sears Comments:

If reducing inflammation is the key for treating perinatal brain injury, then giving the mother higher doses of fish oil would seem to a reasonable approach.
Doctor Barry Sears

Dr. Sears Comments:

Since neurons require omega-3 fatty acids for development in the fetus, lack of their presence in the mother's diet may be an underlying cause of altered neurodevelopment.
Doctor Barry Sears

Dr. Sears Comments:

The author forgot to mention that krill oil is extracted by gasoline (hexane) and then precipitated by nail polish remover (acetone) to get the final product.  I have analyzed krill, oil and it is also rich in PCBs.  Quite a bargain.
Doctor Barry Sears

Dr. Sears Comments:

18-HEPE is the building block for resolvins. You can make adequate levels of 18-HEPE as long as you keep your EPA levels greater than 4% of the total fatty acids in the blood. However, to reach that level of EPA in the blood you, need to take a lot of fish oil, like 5-7.5 grams of EPA and DHA per day. The average American consumes 0.125 grams per day.
Doctor Barry Sears

Dr. Sears Comments:

One of the best ways to manage ADHD is the use of high-dose fish oil to enhance dopamine levels.  One of my co-authors on our research published in 2007 is the leading authority on ADHD.  Somehow the popular press and the medical community seem to ignore his presence on this important piece of the ADHD puzzle.
Doctor Barry Sears

Dr. Sears Comments:

I agree that lowering salt is a good idea for everyone. An even better idea for MS patients is to lower inflammation by consuming more omega-3 fatty acids. I guess they should avoid salted herring. 
Doctor Barry Sears

Dr. Sears Comments:

This is probably another case of fetal programming and helps explains the rapid rise in ADHD along with the dramatic decrease in the intake of omega-3 fatty acids (that also control depression better than anti-depressants). 
Doctor Barry Sears

Dr. Sears Comments:

I am glad that they mentioned my article that demonstrated a 98% reduction in nerve damage in an animal concussion model.  Too bad they didn't mention my article in treating comatose patients with severe brain trauma (Sears et al PharmaNutrition 1:86 (2013) using high-dose omega-3 fatty acids. 
Doctor Barry Sears

Dr. Sears Comments:

You are definitely gambling if your AA/EPA is not between 1.5 and 3.  Since the average American has an AA/EPA ratio of 18, I imagine Wes Welker is in that same range.
Doctor Barry Sears

Dr. Sears Comments:

Unlike this short abstract, a more comprehensive story on CBSnews.com at least recognized my published work on the benefits of high-dose omega-3 fatty acid supplementation in preventing brain damage in an animal concussion study.
Doctor Barry Sears

Dr. Sears Comments:

Diagnostic tests are good, but treatment is better.  High-dose fish oil is a very good treatment to reduce the neuroinflammation that remains after the initial concussion.
Doctor Barry Sears

Dr. Sears Comments:

ADHD is simply a deficiency of dopamine.  It is more epidemic today than it was a century ago.  That is most likely due to the growing deficiency of omega-3 fatty acids in today's diet that would otherwise increase dopamine levels in the brain.
Doctor Barry Sears

Dr. Sears Comments:

There is a strong indication that ALS is a neuro-inflammatory disease so increasing the intake of omega-3 fatty acids makes perfect scientific sense to reduce its development.
Doctor Barry Sears

Dr. Sears Comments:

The fetus needs omega-3 fatty acids for optimal brain development.  All fish have relatively high levels of PCBs as do fish oil in health-food stores.  Look for those brands that have a PCB level of less than 5 ppb (there aren't too many) as the ideal source of omega-3 fatty acids for the fetus.
Doctor Barry Sears

Dr. Sears Comments:

I guess no one at the FDA reads the published data on the use of high-dose fish oil to reduce concussion injuries in animal models.
Doctor Barry Sears

Dr. Sears Comments:

What is neglected in the article are the two great benefits of omega-3 fatty acids.  At low doses it help reduce the initiation of inflammation.  At higher doses it dramatically increases the resolution of existing inflammation.  You need both to live a healthy life.
Doctor Barry Sears

Dr. Sears Comments:

It is amazing how many Americans simply don't realize that most fish oil products are rich in PCBs due to the mistaken assumption that all fish oils are the same.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately, the author forgot to include PCB levels.  This is how you separate a health-food grade from the truly pharmaceutical-grade fish oil.
Doctor Barry Sears

Dr. Sears Comments:

It sounds like someone has been reading my books for the past 20 years.
Doctor Barry Sears

Dr. Sears Comments:

Ironically, one the best ways to treat depression and reduce the anxiety that leads to relapse in alcoholism is high-dose fish oil.  It you have either condition, the supplementation with high-dose fish oil will remarkably improve your ability to manage the condition. 
Doctor Barry Sears

Dr. Sears Comments:

Actually, there is a biological linkage between depression and Parkinson's.  It's called neuroinflammation.
Doctor Barry Sears

Dr. Sears Comments:

Fish oil has always been brain food and will continue to be brain food.  Unfortunately, the intake of long-chain omega-3 fatty acids has dropped by some 90-95% compared to 100 years ago.
Doctor Barry Sears

Dr. Sears Comments:

No need to worry since 85% of the crude fish oil goes to raising farmed-raised fish.  I would rather have humans getting the benefit of omega-3 fatty acids than cheaper salmon enriched with PCBs on my plate.
Doctor Barry Sears

Dr. Sears Comments:

I think it is easier to study a real brain.  When you do, you find that giving high doses of omega-3 fatty acids speeds up recovery by reducing neuroinflammation.
Doctor Barry Sears

Dr. Sears Comments:

It makes more sense to reverse macular degeneration by the use of high-dose fish oil than get ready for living in blindness and the depression that comes with that situation.
Doctor Barry Sears

Dr. Sears Comments:

All of these interventions can reduce inflammation if you give therapeutic levels.
Doctor Barry Sears

Dr. Sears Comments:

Good dietary suggestions, but you are going to need fairly high levels of omega-3 fatty acids (5-7.5 grams of EPA and DHA per day) to have significant pain relief. 
Doctor Barry Sears

Dr. Sears Comments:

Surprisingly balanced article, however, there are great differences between short-chain omega-3 fatty acids (like alpha linolenic acid in chia seeds) and long-chain omega-3 fatty acids in salmon.  Ideally, you want your AA/EPA ratio to be between 1.5 and 3.
Doctor Barry Sears

Dr. Sears Comments:

Definitively not if you take adequate levels of omega-3 fatty acids as I demonstrated in my 2007 paper (Sorgi et al.  "Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder." Nutr J 2007;6:16) where one of my co-authors is the top ADHD expert in America.
Doctor Barry Sears

Dr. Sears Comments:

To maintain weight loss, you have to maintain a calorie-restricted diet.  Such a diet without adequate supplementation with long-chain omega-3 fatty acids can lead to depression.
Doctor Barry Sears

Dr. Sears Comments:

The more omega-3 fatty acids you consume, the more go to the brain.
Doctor Barry Sears

Dr. Sears Comments:

Children with ADHD have lower levels of omega-3 fatty acids than age-matched children.  When you give children with ADHD therapeutic levels of omega-3 fatty acids, their symptoms dramatically improved as I published in 2007. 
Doctor Barry Sears

Dr. Sears Comments:

 I would be very careful of unintended consequences of such plant genetics.
Doctor Barry Sears

Dr. Sears Comments:

Having more brain matter doesn't necessarily mean more intelligence, but it is a start.
Doctor Barry Sears

Dr. Sears Comments:

The article conveniently ignores the Japanese who are largest consumers of fish in the world with the greatest longevity, greatest health span, and low levels of depression and heart disease in the world.  The reason is their low AA/EPA ratio.  To get to that AA/EPA ratio in the Japanese, Americans need to consume between 5 and 7.5 grams of EPA and DHA per day.  No one does. The clinical trials often pointed to as lack of efficacy of fish oil use essentially placebo doses of omega-3 fatty acids.  No wonder they generate placebo results.
Doctor Barry Sears

Dr. Sears Comments:

Dementia is caused by neuroinflammation leading to neuronal death.  The omega-3 fatty acids can cross the blood-brain barrier easily to reduce neuroinflammation and therefore maintain brain volume.
Doctor Barry Sears

Dr. Sears Comments:

Low levels of fish intake help build the brain.  High levels of omega-3 fatty acids promote resolution of inflammation in the brain.
Doctor Barry Sears

Dr. Sears Comments:

Try to get real by focusing on the Japanese who are the largest consumers of fish oil in the world.  When you compare their health to that of Americas quantitatively by using the AA/EPA ratio in both populations, the reason for their superior long-term health is the fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Actually, Facebook does a pretty poor job of selling krill oil or any product, according to research.  This is because Facebook is still used a friends’ portal, and friends feel tacky acting as pitchmen to their friends.  This doesn't stop the high-powered sales presentations from being pushed onto marketers as the ultimate of advertising.
Doctor Barry Sears

Dr. Sears Comments:

True if you use enough to reduce the neuroinflammation induced by the brain injury in the first place.
Doctor Barry Sears

Dr. Sears Comments:

A slight lack of details like how much fish oil they were taking.
Doctor Barry Sears

Dr. Sears Comments:

Inhibiting mTOR always prevents tumor growth.  Adding polyphenols to omega-3 does even a better job of reducing mTOR levels by increasing AMP kinase.
Doctor Barry Sears

Dr. Sears Comments:

That's why your grandmother called fish oil "brain food".
Doctor Barry Sears

Dr. Sears Comments:

Yes it does, but only if you take enough to reduce inflammation in the brain.  That usually requires a lot of omega-3 fatty acids.  Therefore, it has to be very low in PCBs, which unfortunately is not the case when you go to a health- food store or supermarket.
Doctor Barry Sears

Dr. Sears Comments:

Like treating severe brain trauma, if omega-3 fatty acids are to be effective, they must be used at high doses.
Doctor Barry Sears

Dr. Sears Comments:

The benefits are likely due to increased levels of resolvins that shut down ongoing inflammation.
Doctor Barry Sears

Dr. Sears Comments:

Of the listed treatments, high-dose fish oil is the best since dry eye is an inflammatory condition that is best treated by anti-inflammatory omega-3 fatty acids.
Doctor Barry Sears

Dr. Sears Comments:

The real science behind TBI recovery is the reduction of neuroinflammation caused by the TBI in the first place.  The best "drug" for that remains high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

I continually find it difficult to understand when there has been peer-reviewed research for nearly a decade demonstrating that high-dose fish oil effectively manages ADHD, yet physicians ignore the research.  So much for "evidence-based medicine."
Doctor Barry Sears

Dr. Sears Comments:

I think it is more reasonable to consume more polyphenols and omega-3 fatty acids foe maximal heart health, but call me crazy.
Doctor Barry Sears

Dr. Sears Comments:

Since I was mentioned in the article, I should set the record straight that a "pharmaceutical-grade" fish oil is one that has PCB levels of less than 5 ppb (that’s a very low level).  If a company doesn't post the PCB levels in every lot of fish oil they sell, there is usually a good reason.
Doctor Barry Sears

Dr. Sears Comments:

If you have had a brain injury, taking high-dose omega-3 fatty acids to reduce the neuroinflammation it has caused is probably your best protection against early Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

High-dose fish oil does wonders for both depression and heart disease regardless of gender. 
Doctor Barry Sears

Dr. Sears Comments:

The best way to manage any stage of cancer is to reduce inflammation.  If you add high-dose omega-3 fatty acids to the low-dose aspirin, you get an even greater benefit through the increased production of powerful anti-inflammatory hormones known as resolvins.
Doctor Barry Sears

Dr. Sears Comments:

Your best approach to treat depression and prevent weight gain is the use of high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Of all the "superfoods" to be incorporated into an anti-inflammatory diet, chia seeds would definitely be a B player.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately, 95% of all salmon is farm-raised, which is rich in PCBs compared to wild salmon.  That is why wild salmon is so expensive
Doctor Barry Sears

Dr. Sears Comments:

The studies with FAT-1 transgenic mice indicate to get the anti-cancer benefits in humans requires the AA/EPA ratio to be approximately 1.  The current average AA/EPA ratio for Americans is 20.  That means they need a lot of fish oil. 
Doctor Barry Sears

Dr. Sears Comments:

It's low triglycerides that are the medical "breakthrough". The best way to maintain low triglycerides is an anti-inflammatory diet supplemented with high levels of omega-3 fatty acids.

Doctor Barry Sears

Dr. Sears Comments:

Screening for depression is difficult especially with the levels dramatically increasing in all sectors of society.
Doctor Barry Sears

Dr. Sears Comments:

That's true if you are using drugs to lower your blood pressure because they have side effects. That's not the case if you are using diet and exercise to reduce blood pressure.
Doctor Barry Sears

Dr. Sears Comments:

The best way to prevent and treat heart disease is to reduce inflammation in the heart tissue.
Doctor Barry Sears

Dr. Sears Comments:

All fish are contaminated with mercury or PCBs. The best advice is to take highly purified fish-oil capsules to get the necessary omega-3 fatty acids the fetus needs for proper brain development.
Doctor Barry Sears

Dr. Sears Comments:

Nonetheless, cooking omega-3-rich fish, like salmon, remains an art form to most.
Doctor Barry Sears

Dr. Sears Comments:

This is true for all medications. Rather than treating the cause, the usual medical response is adding more drugs.
Doctor Barry Sears

Dr. Sears Comments:

The real enemy in treating obesity comes from using simple slogans. It's not fat or sugar per se, but the combination of insulin and omega-6 fatty acids that increase inflammation in the adipose tissue that cause the expansion and eventual metastasis (like a cancer) of fat to other organs as I described in my book "Toxic Fat."

Doctor Barry Sears

Dr. Sears Comments:

High-dose fish oil good for treating depression in both males and females. It also makes you happier.

Doctor Barry Sears

Dr. Sears Comments:

Both ADHD drugs and high-dose fish oil increase dopamine levels. The high-dose fish oil can reduce many of symptoms of menopause, such as hot flashes. I would stick with the high-dose fish oil.

Doctor Barry Sears

Dr. Sears Comments:

I believe the W.H.O. recommendations for omega-3 intakes are about 10 times too low.
Doctor Barry Sears

Dr. Sears Comments:

The differences may be due to estrogen levels. But in any case, it takes a long time for a complete recovery. High-dose fish oil will reduce that recovery time for either sex by reducing neuroinflammation.

Doctor Barry Sears

Dr. Sears Comments:

Only about 5% of the short chain omega-3 fatty acids in flaxseed oil get converted to EPA and even less to DHA (about 1%). Only EPA and DHA provide the anti-inflammatory effects of omega-3 fatty acids. Since I recommend about 1600 mg of EPA per day, this means you need to consume about 64 grams of flaxseed oil per day to get that level of EPA. Relative to getting enough DHA, I agree with the article that purchasing an algae form is the most cost-effective approach. However you will need about 800 mg per day to meet my minimum requirements for DHA.

Doctor Barry Sears

Dr. Sears Comments:

The omega-3 fatty acids are fine, it's just the mercury in the tuna and the glucose in the sandwich that are less desirable.
Doctor Barry Sears

Dr. Sears Comments:

If you give a placebo dose of omega-3 fatty acids, you tend to get placebo effects.
Doctor Barry Sears

Dr. Sears Comments:

I simply tell people let the blood determine how much EPA and DHA you need. Take enough to keep the AA/EPA ratio between 1.5 and 3.

Doctor Barry Sears

Dr. Sears Comments:

It's a little more complicated than simply chocolate. It is the cocoa polyphenols most which are destroyed in making chocolate.
Doctor Barry Sears

Dr. Sears Comments:

I wish it were a fad, but it's indicative of the growing neurological problems that dietary changes have induced in our population. These epigenetic changes are not going away very soon.
Doctor Barry Sears

Dr. Sears Comments:

When The Mediterranean Zone appears in September, the real science behind the Mediterranean diet will be explained.
Doctor Barry Sears

Dr. Sears Comments:

The increase in "healthy" omega-6 fatty acids is the underlying reason for the acceleration of chronic disease including Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

Even the algae oil sold for human consumption is genetically modified.
Doctor Barry Sears

Dr. Sears Comments:

Once such mediation to lower stress is high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Too bad there was no mention of reducing inflammation in their fat cells.
Doctor Barry Sears

Dr. Sears Comments:

Cardiovascular conditions like heart failure are linked to increased inflammation. So is depression.
Doctor Barry Sears

Dr. Sears Comments:

If you are going to eat fish for health benefits, the intelligent choice is salmon not tilapia that is rich in omega-6 fatty acids.