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Doctor Barry Sears

Dr. Sears Comments:

The growing waist circumference is indicative of increasing insulin resistance in the liver and the muscles.  It is one of the clinical signs for the development of metabolic syndrome or pre-diabetes.
Doctor Barry Sears

Dr. Sears Comments:

The reason why the first two new obesity drugs have not sold well is because they don't work effectively. This new drug should be no different. The only obesity drug that sold well was Fen-Phen because it shut down appetite very effectively. Of course, it had a few side effects like death, but it worked very well in those who didn't die.
Doctor Barry Sears

Dr. Sears Comments:

How anyone can think the still increasing obesity rates are a good sign is beyond belief.
Doctor Barry Sears

Dr. Sears Comments:

 I don't think anyone who actually reads the CDC data would come to the conclusion that we are winning the war against obesity.
Doctor Barry Sears

Dr. Sears Comments:

It's past wake-up time for China as it already has the greatest number of diabetics in the world, and the percentage is growing. 
Doctor Barry Sears

Dr. Sears Comments:

Childhood trauma not only causes increases in cortisol but also epigenetic changes that can last a lifetime.
Doctor Barry Sears

Dr. Sears Comments:

t's not that simple.  It is obesity becoming metabolic syndrome (pre-diabetes) then going on to type-2 diabetes.  The progression is caused by the flow of inflammation from the fat cells to the liver to the pancreas.
Doctor Barry Sears

Dr. Sears Comments:

You don't get diabetes by being fat. You get diabetes by first developing metabolic syndrome (pre-diabetes) before the beta cells in the pancreas are destroyed causing diabetes. Both metabolic syndrome and diabetes are caused by increased inflammation. If you are fat and not inflamed, you fall into the category of "metabolically healthy obese" which is about 20-30% of the obese population. 
Doctor Barry Sears

Dr. Sears Comments:

It's not about gaining less weight, but reducing the inflammation before pregnancy that generates the health benefits to both the mother and child.
Doctor Barry Sears

Dr. Sears Comments:

Why stop there?  They should also tax bread and pasta since they have a greater impact on blood glucose levels than sugary sodas. After all, glucose is glucose.
Doctor Barry Sears

Dr. Sears Comments:

This is simply a case of the epidemic spread of diet-induced inflammation.  My new book, “The Mediterranean Zone,” explores this in greater detail and explains how to overcome it.
Doctor Barry Sears

Dr. Sears Comments:

Even short periods of sleep deprivation will increase cortisol and insulin resistance.  Do it consistently, and you gain weight.
Doctor Barry Sears

Dr. Sears Comments:

One of the best ways to ensure a healthy gut is to increase your intake of polyphenols.
Doctor Barry Sears

Dr. Sears Comments:

The problem with obesity is the inflammation it generates.  Reduce that inflammation, and you can live with the excess body weight.  That's why a significant percentage of obese individuals are "metabolically healthy obese".
Doctor Barry Sears

Dr. Sears Comments:

Just like early nutrition  can start epigenetic markers that last a lifetime, apparently significant changes in the microbial composition of the gut can do likewise.
Doctor Barry Sears

Dr. Sears Comments:

The obesity for these preschoolers started in the womb via fetal programming, and the epigenetic changes are likely to be carried for the rest of their lives.
Doctor Barry Sears

Dr. Sears Comments:

As long as you have an Edmonton Obesity Staging System (EOSS) of zero, you seem to remain healthy regardless of your weight.
Doctor Barry Sears

Dr. Sears Comments:

If you take out the words "obesity and overweight" in the figure in the article and replace them with inflammation, then it all makes sense.  Weight gain is one of the first indications of increased inflammation in the body and specifically in the fat cells.
Doctor Barry Sears

Dr. Sears Comments:

Epigenetics is making the hope of personalized medicine by simply looking at the gene sequences more and more of a pipe dream.  
Doctor Barry Sears

Dr. Sears Comments:

At least this article makes the direct linkage between the inflammation caused by obesity with the inflammation that is associated with RA.
Doctor Barry Sears

Dr. Sears Comments:

The best way to overcome a lack of dopamine is to increase its levels by high-dose fish oil and maintain stable blood-glucose levels.
Doctor Barry Sears

Dr. Sears Comments:

It is also true that very few parents believe their children are average.  The data is clear that exercise in children will not cause significant weight loss even if they become more fit.  The real weight loss starts with the diet.
Doctor Barry Sears

Dr. Sears Comments:

A high-fat diet in animal studies is usually high in saturated fat.  The saturated fat can activate toll-like receptors on the surface of every cell to increase inflammation.  If there is any cell in the body that is sensitive to inflammation, it is nerve cells.
Doctor Barry Sears

Dr. Sears Comments:

There is a zone for carbohydrates.  Yes, in excess they are bad as they produce more insulin.  When they are greatly restricted, the levels of the hormone cortisol are increased. You are looking for the sweet spot between those two hormonal extremes.
Doctor Barry Sears

Dr. Sears Comments:

The excess weight can have the benefit of forcing a person to have increased muscle mass that is usually protective in chronic disease conditions.
Doctor Barry Sears

Dr. Sears Comments:

Most likely this is due to differences in dopamine response.  It is known that obesity dampens down the reward signals from dopamine thus making pictures of appetizing food become even more appealing.
Doctor Barry Sears

Dr. Sears Comments:

The globalization of food is causing a globalization of obesity followed by diabetes and Alzheimer's.  Not a pretty picture as I explain in my new book, “The Mediterranean Zone.”  But there is a way out following an anti-inflammatory diet for lifetime.
Doctor Barry Sears

Dr. Sears Comments:

Selling health means selling the continued control of diet-induced inflammation.  That's going to be a tough sell.
Doctor Barry Sears

Dr. Sears Comments:

n animal breeding it is known that the closer the temperature is to 72 F, the more the animal eats and more quickly it fattens up.  The same is true of humans.  One factor in our obesity epidemic is the desire to maintain 72 F year around.  If you are cold in the winter, you burn more fat.  If you are hot in the summer, you eat less food.  
Doctor Barry Sears

Dr. Sears Comments:

These are all excellent strategies assuming you don't irritate your friends.
Doctor Barry Sears

Dr. Sears Comments:

This article points out many of the inconvenient truths about obesity.  The most important in my opinion is the growing levels of diet-induced inflammation.
Doctor Barry Sears

Dr. Sears Comments:

That elderly group is also at greatest risk for developing type 2 diabetes.  With that condition, the likelihood of developing heart disease or dementia significantly increases.  Losing weight is difficult as you age, but controlling inflammation is not. 
Doctor Barry Sears

Dr. Sears Comments:

Before you start giving kudos, it would be nice to see if the trend is real or simply a statistical blip.
Doctor Barry Sears

Dr. Sears Comments:

Obesity is simply the accumulation of excess body fat.  It doesn't become a disease unless that excess body fat begins to cause organ malfunction.  Someone being a "metabolically healthy obese" individual is not an oxymoron.
Doctor Barry Sears

Dr. Sears Comments:

The primary complication of obesity in pregnancy is insulin resistance.  You can reduce insulin resistance rapidly on an anti-inflammatory diet before you see significant weight loss.
Doctor Barry Sears

Dr. Sears Comments:

That's called good marketing whatever the health consequences.
Doctor Barry Sears

Dr. Sears Comments:

Increased visceral body fat is strongly driven by inflammation.  COPD is an inflammatory condition.  The connection seems obvious to me.
Doctor Barry Sears

Dr. Sears Comments:

Both conditions have an inflammatory component.  Moderate exercise is anti-inflammatory.  That's why moderate, consistent exercise can be beneficial for both conditions.
Doctor Barry Sears

Dr. Sears Comments:

No one has perfect genes, but you can overcome a bad genetic hand by working on the things alter epigenetics and, therefore, the expression of your genes.  Those things are your diet, exercise, and stress reduction.
Doctor Barry Sears

Dr. Sears Comments:

Natural agents that increase satiety should be the next major area of obesity research.  There are a lot of drugs that have increased satiety in the past (cocaine, amphetamines, Fen-Phen, etc.), but they all had some side effects.  
Doctor Barry Sears

Dr. Sears Comments:

Both asthma and obesity are inflammatory conditions.  Obesity feeds the inflammation associated with the symptoms of asthma.
Doctor Barry Sears

Dr. Sears Comments:

Usually high temperature decreases appetite and cold temperature increases shivering to maintain body temperature. With increased air conditioning in the South and heating in the North, those normal control mechanisms are circumvented.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately, the "causes" of obesity outlined in the article may be only the tip of the inflammation iceberg that is occurring on a worldwide basis.
Doctor Barry Sears

Dr. Sears Comments:

They forgot to add the increase in inflammation and epigenetic changes caused by fetal programming.
Doctor Barry Sears

Dr. Sears Comments:

The one thing that does fit all is increased satiety.
Doctor Barry Sears

Dr. Sears Comments:

Money and prestige talk and safety walks when it comes to the World Cup.
Doctor Barry Sears

Dr. Sears Comments:

As obesity and diabetes continue is escalate, having more Hollywood documentaries on sugar alone will divert attention from the real cause, which is inflammation. It is difficult to make an entertaining documentary on inflammation.

Doctor Barry Sears

Dr. Sears Comments:

Gastric bypass surgery can be seen to manage diabetes, not cure it. The primary effect probably comes from the changes in the gut hormones that control appetite in the brain.

Doctor Barry Sears

Dr. Sears Comments:

You are not going to have any impact on obesity until you begin to reduce the inflammation caused by the diet that activates any potential underlying genetic propensity.
Doctor Barry Sears

Dr. Sears Comments:

I like to believe my books over the last 20 years, including my last book, Toxic Fat, have put forth a comprehensive understanding of obesity as an inflammatory disease that leads to the formation of a "fat trap" that prevents the normal metabolism of incoming dietary calories. Unfortunately, that viewpoint of obesity remains too sophisticated for many physicians (and politicians) to grasp.

Doctor Barry Sears

Dr. Sears Comments:

I couldn't agree more with the conclusion. Glucose is glucose whatever the source, but combine high levels of glucose with high levels of omega-6 fatty acids, and then you have a real inflammation problem on your hands.

Doctor Barry Sears

Dr. Sears Comments:

Sugar sweetened soda causes obesity because it is rich in glucose. However far more glucose is supplied in the American diet by bread, pasta, and rice. If you are going to tax soda, then you also tax the glucose content of bread, pasta, and rice.

Doctor Barry Sears

Dr. Sears Comments:

A far better approach is to increase satiety. This is primarily done by following an anti-inflammatory diet to enhance the intensity of satiety signals being received by the hypothalamus.
Doctor Barry Sears

Dr. Sears Comments:

You'll have greater results by taxing all the foods that appear in the aisles of the supermarket (i.e., processed foods) and allowing those on the periphery go tax-free.
Doctor Barry Sears

Dr. Sears Comments:

One of the best exercise monitors is simply weighing yourself every day, measuring your waist circumstance and then keeping the results in a daily log.

Doctor Barry Sears

Dr. Sears Comments:

Obesity will continue to grow with increased inflammation. For many the obesity leads to diabetes and eventually Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

One of the primary causes of the activation of the FTO gene is increased cellular inflammation as we age.
Doctor Barry Sears

Dr. Sears Comments:

Cheaper food also means more inflammatory food.
Doctor Barry Sears

Dr. Sears Comments:

The hormone GLP-1 that is increased by the drug can also be enhanced by lowering the glycemic load of the diet. Here's your choice: inject a drug or eat lots of vegetables.

Doctor Barry Sears

Dr. Sears Comments:

This is just what we need: Hollywood explaining nutrition. It's like a remake of “Wag The Dog.” I wish life were as simple as portrayed in the film.

Doctor Barry Sears

Dr. Sears Comments:

This article doesn't help with the confusion as there is no mention of increased inflammation as an underlying cause of obesity.
Doctor Barry Sears

Dr. Sears Comments:

I don't think there is any optimism about the rising rates of diabetes.
Doctor Barry Sears

Dr. Sears Comments:

Both conditions are a consequence of increased inflammation.
Doctor Barry Sears

Dr. Sears Comments:

http://www.foxnews.com/health/2014/04/21/dealing-with-obesity-while-trying-to-conceive/
Doctor Barry Sears

Dr. Sears Comments:

Neglected in the story is that obese children are becoming even fatter although the total obesity has remained constant.