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Doctor Barry Sears

Dr. Sears Comments:

A long article with the summary that diet-induced inflammation makes you fat.  I wish I had thought of that.
Doctor Barry Sears

Dr. Sears Comments:

Another explanation is that killing off friendly bacteria allows repopulation of the gut with more pathogenic bacteria whose toxins and bacterial fragments can increase inflammatory responses in the child that lead to increased inflammation in the fat cells, causing insulin resistance.
Doctor Barry Sears

Dr. Sears Comments:

Even though the symptoms of heart attack in women are different than men, the underlying cause is the same:  Increased cellular inflammation.  The primary solution to heart disease is not reducing cholesterol but reducing inflammation.
Doctor Barry Sears

Dr. Sears Comments:

Here's a better recommendation:  Reduce inflammation in the arterial wall that causes the rupture of soft vulnerable plaques.  That will do more for you than taking a walk.
Doctor Barry Sears

Dr. Sears Comments:

The only way to treat a leaky gut is an anti-inflammatory diet coupled with high-dose omega-3 fatty acids and polyphenols to help alter the microbial composition in the gut. 
Doctor Barry Sears

Dr. Sears Comments:

Teenage years are characterized by rapid growth of bone and muscle, both requiring increasing levels of growth hormone.  This is why teenagers are constantly hungry.  However, high levels of insulin can block the release of growth hormone.  At the molecular level this is probably induced by increased inflammation in the pituitary gland.  Teenagers should always exercise, but overweight teenagers should also be following an anti-inflammatory diet.
Doctor Barry Sears

Dr. Sears Comments:

Don't kid yourself as the next epidemic that is brewing is Alzheimer's because those with diabetes are twice as likely to get Alzheimer's.  Usually there is a 15-year lag period between the start of one epidemic form of inflammation to another.  The obesity epidemic started in 1980, the diabetes epidemic started in 1995, and the now the fastest growing cause of death is Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

Besides a lot of rest, the child also needs a lot of fish oil to reduce the neuroinflammation in the brain.
Doctor Barry Sears

Dr. Sears Comments:

I certainly stand by my quote in that article.
Doctor Barry Sears

Dr. Sears Comments:

Two of the primary causes of cataracts are trauma and radiation. Both generate inflammation.  Polyphenols and omega-3 fatty acids are much more powerful anti-inflammatory agents than vitamin E and selenium.
Doctor Barry Sears

Dr. Sears Comments:

The published data are clear that even high-dose fish oil doesn't cause increased bleeding if the AA/EPA ratio remains above 1.  Relative to the declining rate of CHD mortality in the last 30 years, give the credit to reduced smoking, not increased statins.
Doctor Barry Sears

Dr. Sears Comments:

Both conditions (as well as diabetes) are connected by increased inflammation.  This is why an anti-inflammatory diet is your best ally for aging well.
Doctor Barry Sears

Dr. Sears Comments:

The growing waist circumference is indicative of increasing insulin resistance in the liver and the muscles.  It is one of the clinical signs for the development of metabolic syndrome or pre-diabetes.
Doctor Barry Sears

Dr. Sears Comments:

The best defense against Alzheimer's is reducing inflammation.  The best drug is the combination of an anti-inflammatory diet and high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

It's not a high-fat diet, but a high-fat diet rich in omega-6 and saturated fatty acids, as both can cause inflammation in the brain.
Doctor Barry Sears

Dr. Sears Comments:

Very striking evidence that serotonin may be the cause of depression.  A more likely candidate is inflammation disrupting the communication of neurotransmitters into the interior of the neuron.  This is why high-dose fish oil is effective in treating depression.
Doctor Barry Sears

Dr. Sears Comments:

It is still clear that in women statin use increases diabetes incidence. A better alternative is an anti-inflammatory diet to reduce insulin levels that cause the excess production of cholesterol in the liver in the first place.
Doctor Barry Sears

Dr. Sears Comments:

This is a consequence of fetal programming in which hyperinsulinemia can leave epigenetic marks in the DNA of the fetus that predisposes them to obesity, diabetes, and diabetes.  Much of this is explained in my new book, “The Mediterranean Zone,” coming out in the fall.
Doctor Barry Sears

Dr. Sears Comments:

Excellent point on olive oil and fish oil vs. saturated fats that is found in the correction to the widely quoted article that led to the media report that saturated fats are good. The data demonstrate that saturated fats cause inflammation, whereas olive oil and fish oil have more anti-inflammatory fats.
Doctor Barry Sears

Dr. Sears Comments:

If reducing inflammation is the key for treating perinatal brain injury, then giving the mother higher doses of fish oil would seem to a reasonable approach.
Doctor Barry Sears

Dr. Sears Comments:

Since neurons require omega-3 fatty acids for development in the fetus, lack of their presence in the mother's diet may be an underlying cause of altered neurodevelopment.
Doctor Barry Sears

Dr. Sears Comments:

Diabetes also fuels heart disease and Alzheimer's.  It's not the diabetes, but the inflammation that compromises the immune system.
Doctor Barry Sears

Dr. Sears Comments:

18-HEPE is the building block for resolvins. You can make adequate levels of 18-HEPE as long as you keep your EPA levels greater than 4% of the total fatty acids in the blood. However, to reach that level of EPA in the blood you, need to take a lot of fish oil, like 5-7.5 grams of EPA and DHA per day. The average American consumes 0.125 grams per day.
Doctor Barry Sears

Dr. Sears Comments:

I agree that lowering salt is a good idea for everyone. An even better idea for MS patients is to lower inflammation by consuming more omega-3 fatty acids. I guess they should avoid salted herring. 
Doctor Barry Sears

Dr. Sears Comments:

t's not that simple.  It is obesity becoming metabolic syndrome (pre-diabetes) then going on to type-2 diabetes.  The progression is caused by the flow of inflammation from the fat cells to the liver to the pancreas.
Doctor Barry Sears

Dr. Sears Comments:

You don't get diabetes by being fat. You get diabetes by first developing metabolic syndrome (pre-diabetes) before the beta cells in the pancreas are destroyed causing diabetes. Both metabolic syndrome and diabetes are caused by increased inflammation. If you are fat and not inflamed, you fall into the category of "metabolically healthy obese" which is about 20-30% of the obese population. 
Doctor Barry Sears

Dr. Sears Comments:

A better game-changer is high-dose fish oil (Tavazzi L et al. "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial."  Lancet 2008 Oct 4;372(9645):1223-30)
Doctor Barry Sears

Dr. Sears Comments:

If you really want to reduce concussions, simply outlaw heading in the first place.
Doctor Barry Sears

Dr. Sears Comments:

You are definitely gambling if your AA/EPA is not between 1.5 and 3.  Since the average American has an AA/EPA ratio of 18, I imagine Wes Welker is in that same range.
Doctor Barry Sears

Dr. Sears Comments:

Unlike this short abstract, a more comprehensive story on CBSnews.com at least recognized my published work on the benefits of high-dose omega-3 fatty acid supplementation in preventing brain damage in an animal concussion study.
Doctor Barry Sears

Dr. Sears Comments:

Diagnostic tests are good, but treatment is better.  High-dose fish oil is a very good treatment to reduce the neuroinflammation that remains after the initial concussion.
Doctor Barry Sears

Dr. Sears Comments:

This is due to fetal programing that sets epigenetic marks that will last a lifetime.  My new book, “The Mediterranean Zone,” goes into more detail how this happens.
Doctor Barry Sears

Dr. Sears Comments:

ADHD is simply a deficiency of dopamine.  It is more epidemic today than it was a century ago.  That is most likely due to the growing deficiency of omega-3 fatty acids in today's diet that would otherwise increase dopamine levels in the brain.
Doctor Barry Sears

Dr. Sears Comments:

There is a strong indication that ALS is a neuro-inflammatory disease so increasing the intake of omega-3 fatty acids makes perfect scientific sense to reduce its development.
Doctor Barry Sears

Dr. Sears Comments:

What is neglected in the article are the two great benefits of omega-3 fatty acids.  At low doses it help reduce the initiation of inflammation.  At higher doses it dramatically increases the resolution of existing inflammation.  You need both to live a healthy life.
Doctor Barry Sears

Dr. Sears Comments:

One of the best ways to ensure a healthy gut is to increase your intake of polyphenols.
Doctor Barry Sears

Dr. Sears Comments:

The problem with obesity is the inflammation it generates.  Reduce that inflammation, and you can live with the excess body weight.  That's why a significant percentage of obese individuals are "metabolically healthy obese".
Doctor Barry Sears

Dr. Sears Comments:

It sounds like someone has been reading my books for the past 20 years.
Doctor Barry Sears

Dr. Sears Comments:

Stress causes inflammation, and inflammation accelerates diabetes.
Doctor Barry Sears

Dr. Sears Comments:

The best way to treat diabetes and prevent hypoglycemia remains an anti-inflammatory diet and exercise.
Doctor Barry Sears

Dr. Sears Comments:

Actually, there is a biological linkage between depression and Parkinson's.  It's called neuroinflammation.
Doctor Barry Sears

Dr. Sears Comments:

The reason is that aspirin can both lower the initiation of inflammation and at low doses increases the resolution of inflammation.  Tumors thrive on continuous inflammation.
Doctor Barry Sears

Dr. Sears Comments:

No, surprisingly, since MS is a disease of neuroinflammation, not a Vitamin D deficiency.
Doctor Barry Sears

Dr. Sears Comments:

Stick with the polyphenols in extra-virgin olive oil and the omega-3 fatty acids in salmon, but you need therapeutic amounts of both to reduce neuro-inflammation.  As far the MIT "brain drink," save your money and taste buds.
Doctor Barry Sears

Dr. Sears Comments:

Any impact that causes the brain to slosh around in the skull is going to cause inflammation.
Doctor Barry Sears

Dr. Sears Comments:

I have even higher hopes on reducing the neuroinflammation in the brain that causes Parkinson's by using high-dose fish oil.  It's ready now and is a lot more elegant than a vaccine.
Doctor Barry Sears

Dr. Sears Comments:

It makes more sense to reverse macular degeneration by the use of high-dose fish oil than get ready for living in blindness and the depression that comes with that situation.
Doctor Barry Sears

Dr. Sears Comments:

Here's a better idea based on science.  Follow an anti-inflammatory diet to control blood glucose levels and take high levels of omega-3 fatty acids.
Doctor Barry Sears

Dr. Sears Comments:

Maybe if someone on Dr. Oz's staff reads “The Mediterranean Zone” when it comes out in the fall, then he might be able to discuss the Mediterranean diet in more scientific detail.
Doctor Barry Sears

Dr. Sears Comments:

If you want to lose excess fat and detox at the same time, simply follow an anti-inflammatory diet.
Doctor Barry Sears

Dr. Sears Comments:

If you take out the words "obesity and overweight" in the figure in the article and replace them with inflammation, then it all makes sense.  Weight gain is one of the first indications of increased inflammation in the body and specifically in the fat cells.
Doctor Barry Sears

Dr. Sears Comments:

Epigenetics is making the hope of personalized medicine by simply looking at the gene sequences more and more of a pipe dream.  
Doctor Barry Sears

Dr. Sears Comments:

Dementia is caused by neuroinflammation leading to neuronal death.  The omega-3 fatty acids can cross the blood-brain barrier easily to reduce neuroinflammation and therefore maintain brain volume.
Doctor Barry Sears

Dr. Sears Comments:

It should be the case against excess glucose.  If you overload the system with glucose, especially coupled with excess omega-6 fatty acid consumption, you generate excess inflammation.  This has been the cornerstone of my Zone technology for the past 20 years.  The largest supply of glucose in the diet is grains and starches, not added sugar.  Keep them all to a minimum by eating primarily vegetables and fruits as your carbohydrate source.  Furthermore, the polyphenols in vegetables and fruits also eliminate any possible oxidative damage coming from either glucose or fructose. 
Doctor Barry Sears

Dr. Sears Comments:

As pointed out in the article, both MS and osteoporosis are inflammatory conditions.  This is why high-dose fish oil can be effective in treating both.
Doctor Barry Sears

Dr. Sears Comments:

If anyone would read the literature, they would find out that statins have anti-inflammatory effects, which may explain their potential benefits in wound healing.
Doctor Barry Sears

Dr. Sears Comments:

Both depression and anxiety are linked to inflammation.  One of the consequences of insomnia is increased insulin levels.  If you mix increased insulin with excess omega-6 fatty acids, then you get more arachidonic acid that leads to inflammation.
Doctor Barry Sears

Dr. Sears Comments:

It's the excess glucose.  It is highly reactive chemically and can cause inflammation as a consequence via oxidative stress.  The brain needs some glucose but not too much.
Doctor Barry Sears

Dr. Sears Comments:

At least the article hints at inflammation as the linkage of the two conditions.  The fact that high-dose fish oil treats both conditions would also reinforce that inflammatory link.
Doctor Barry Sears

Dr. Sears Comments:

The best way to treat a concussion is to reduce the neuroinflammation caused by the concussion.  High-dose fish oil remains the best way to achieve that goal.
Doctor Barry Sears

Dr. Sears Comments:

This demonstrates the power of the placebo in lower back pain relief as well as the power of great advertising by Tylenol.
Doctor Barry Sears

Dr. Sears Comments:

Melatonin is one the few anti-oxidants that can cross the blood-brain barrier.  However, the cause of oxidative stress in traumatic brain injury is neuroinflammation.  That is far more effectively reduced with high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

I suspect that younger women with heart disease are more inflamed to begin with to overcome the protective benefits of estrogen.
Doctor Barry Sears

Dr. Sears Comments:

Actually depression is like diabetes as both conditions have a strong inflammatory component working in different directions.  In diabetes, the inflammation is disrupting normal glucose metabolism, whereas in depression the inflammation is disturbing the flow of neural transmitters.
Doctor Barry Sears

Dr. Sears Comments:

As bad as the NFL and NHL are about talking about concussions, FIFA makes them look like paragons of virtue.  Apparently money talks, and safety walks in soccer.
Doctor Barry Sears

Dr. Sears Comments:

This should not be surprisingly since any neuroinflammation will disrupt the quality of sleep, and Parkinson's is a neuroinflammatory disease.
Doctor Barry Sears

Dr. Sears Comments:

This article points out many of the inconvenient truths about obesity.  The most important in my opinion is the growing levels of diet-induced inflammation.
Doctor Barry Sears

Dr. Sears Comments:

Both diseases are driven by inflammation as is described in greater detail in my new book, “The Mediterranean Zone,” that comes out in September.
Doctor Barry Sears

Dr. Sears Comments:

Both conditions have an inflammatory component.  Moderate exercise is anti-inflammatory.  That's why moderate, consistent exercise can be beneficial for both conditions.
Doctor Barry Sears

Dr. Sears Comments:

The best way to treat brain trauma is to reduce neuroinflammation.  More red blood cells will not do that.  High-dose fish oil will.
Doctor Barry Sears

Dr. Sears Comments:

It's called fetal programming, and I explain in greater detail in my new book, The Mediterranean Zone, which comes out in September.
Doctor Barry Sears

Dr. Sears Comments:

Since Lewy body dementia and Alzheimer's appear to have a common inflammatory basis (J Mrak RE1 and Griffin WS.  "Common inflammatory mechanisms in Lewy body disease and Alzheimer disease." Neuropathol Exp Neurol. 2007 66(8):683-6), it would make sense that an anti-inflammatory diet and high-dose fish oil would be the best way to manage both conditions.
Doctor Barry Sears

Dr. Sears Comments:

The best approach to reduce gestational diabetes is an anti-inflammatory diet.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately, the "causes" of obesity outlined in the article may be only the tip of the inflammation iceberg that is occurring on a worldwide basis.
Doctor Barry Sears

Dr. Sears Comments:

I suspect that there is also a role for increased inflammation in these observations.
Doctor Barry Sears

Dr. Sears Comments:

If you have one inflammatory disease (i.e. COPD), you will like have another one brewing somewhere in the body.
Doctor Barry Sears

Dr. Sears Comments:

This is the same reason that people who may be genetically predisposed to Huntington's disease don't want to get tested since they can't do much about stopping it.
Doctor Barry Sears

Dr. Sears Comments:

There is a zone for everything, including exercise. Interval training allows you to get all the benefits of exercise in a much shorter period of time. That being said, the best exercise remains not sitting down. That's why I am writing these comments at a standing desk.

Doctor Barry Sears

Dr. Sears Comments:

Early menopause means an early increase in insulin levels as estrogen levels drop. If you are eating a diet rich in omega-6 fatty acids, this increases insulin levels and becomes a sure-fire prescription for increased inflammation that leads to increased risk of heart failure.
Doctor Barry Sears

Dr. Sears Comments:

Well-educated individuals usually have better diets and more resources.
Doctor Barry Sears

Dr. Sears Comments:

Fatty liver is the next epidemic rising in America. Like diabetes and atherosclerosis it's primary cause is increased inflammation.