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Doctor Barry Sears

Dr. Sears Comments:

Excellent point on olive oil and fish oil vs. saturated fats that is found in the correction to the widely quoted article that led to the media report that saturated fats are good. The data demonstrate that saturated fats cause inflammation, whereas olive oil and fish oil have more anti-inflammatory fats.
Doctor Barry Sears

Dr. Sears Comments:

18-HEPE is the building block for resolvins. You can make adequate levels of 18-HEPE as long as you keep your EPA levels greater than 4% of the total fatty acids in the blood. However, to reach that level of EPA in the blood you, need to take a lot of fish oil, like 5-7.5 grams of EPA and DHA per day. The average American consumes 0.125 grams per day.
Doctor Barry Sears

Dr. Sears Comments:

It's not the fruits, but the polyphenols in the fruits that are important.  As to why, I explain this greater detail in my new book, “The Mediterranean Zone,” coming out in the fall.
Doctor Barry Sears

Dr. Sears Comments:

Large amounts of caffeine and alcohol are usually a bad combination.
Doctor Barry Sears

Dr. Sears Comments:

A better game-changer is high-dose fish oil (Tavazzi L et al. "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial."  Lancet 2008 Oct 4;372(9645):1223-30)
Doctor Barry Sears

Dr. Sears Comments:

It's not the alcohol, but the polyphenols in the alcohol that have the health benefits.
Doctor Barry Sears

Dr. Sears Comments:

Good start with recommending fruits and vegetables to get polyphenols, but it only helps if they are balanced by low-fat protein and restriction of omega-6 and saturated fats.
Doctor Barry Sears

Dr. Sears Comments:

It's the combination of polyphenols and lowering of the glycemic load as I explain in greater detail in my new book, “The Mediterranean Zone.”
Doctor Barry Sears

Dr. Sears Comments:

The biggest lingering problem of TBI is not bleeding but continuing neuroinflammation in the brain.
Doctor Barry Sears

Dr. Sears Comments:

Aspirin is great for secondary prevention of heart attack, but like statins it is not very good for primary prevention.
Doctor Barry Sears

Dr. Sears Comments:

I think an ounce of prevention is worth a pound of cure.  The best long-term warning signal of an impeding heart attack is an elevated AA/EPA ratio.
Doctor Barry Sears

Dr. Sears Comments:

If anyone would read the literature, they would find out that statins have anti-inflammatory effects, which may explain their potential benefits in wound healing.
Doctor Barry Sears

Dr. Sears Comments:

As usual, nutrition is a little more complex than a Harvard epidemiological analysis.  You have to maintain the protein-to-glycemic load of the diet to maintain the correct hormonal response as well as balance the levels of omega-6 and omega-3 fats to control inflammation.
Doctor Barry Sears

Dr. Sears Comments:

Statins have some anti-inflammatory benefits.  But so does an anti-inflammatory diet.  When combined with omega-3 fatty acids and polyphenols, you are likely to have a far better benefit in reducing cancer incidence.
Doctor Barry Sears

Dr. Sears Comments:

Mortality from cardiovascular disease has been dropping in linear fashion since 1970, according to data from the American Heart Association.  That was 25 years before the first statins were ever introduced.  Maybe cholesterol was never the problem in the first place.
Doctor Barry Sears

Dr. Sears Comments:

Simple lifestyle choices to write about, incredibly difficult ones to implement on a lifetime basis.
Doctor Barry Sears

Dr. Sears Comments:

Aspirin is also an old drug that still works pretty well.  Niacin will reduce cholesterol levels with a lot of side-effects at levels required for cholesterol reduction.  Of course, the more you follow an anti-inflammatory diet, the less niacin you need as well as lower levels of statins (ideally zero in both cases) to bring cholesterol into normal levels.
Doctor Barry Sears

Dr. Sears Comments:

I suspect that younger women with heart disease are more inflamed to begin with to overcome the protective benefits of estrogen.
Doctor Barry Sears

Dr. Sears Comments:

It is the potassium-to-sodium ratio that is more important than total sodium.  The best way to increase potassium is to eat more vegetables and fruits.  For diabetics, this lowering of the glycemic load of the diet is the best defense against heart disease.
Doctor Barry Sears

Dr. Sears Comments:

The article forgets to mention that each of those sources of probiotics is also rich in protein.  Increased protein intake relative to carbohydrates will also help lower blood pressure.
Doctor Barry Sears

Dr. Sears Comments:

Before you start injecting stem cells to treat inflammatory diseases, how about using high-dose fish oil to not only reduce the inflammation, but also create the resolution that builds new healthy tissue.
Doctor Barry Sears

Dr. Sears Comments:

Nuts are great sources of polyphenols.  Unfortunately, they are also great sources of fat that has to go somewhere once you consume it.  If you are not burning it up, then you store it in your fat cells.  When they get stuffed, then it goes to other cells and causes lipotoxicity, which is major contributor to diabetes.
Doctor Barry Sears

Dr. Sears Comments:

I didn't read anything about reducing levels of inflammation.  Japanese males have the same cholesterol levels as American males, but 1/7 the number of deaths from heart disease maybe because their level of inflammation as measured by the AA/EPA ratio is 7 times lower.
Doctor Barry Sears

Dr. Sears Comments:

Somehow I would be feel more comfortable with a mechanical device that can be replaced than gene therapy that can't.
Doctor Barry Sears

Dr. Sears Comments:

These facts have been known for a long time, but drug companies still sell such drugs.
Doctor Barry Sears

Dr. Sears Comments:

A more important factor might the potassium-to-sodium ratio.
Doctor Barry Sears

Dr. Sears Comments:

When some researcher suggests possible harm from a billion-dollar-a-year class of drugs, you can imagine some in the medical community will complain as opposed to doing more studies to confirm or disprove the initial findings.  I think this is called science.
Doctor Barry Sears

Dr. Sears Comments:

Simple thinking leads to pathetic results.  You need some carbs for the brain.  Most credible medical researchers would state that is between 100-150 grams per day.  Less than that, cortisol levels will increase to break down muscle into glucose.  More than that, excess insulin is produced.  You need a zone of carbohydrates.  Maybe I will write a book on that subject.
Doctor Barry Sears

Dr. Sears Comments:

All good food choices if you keep them balanced when you eat them.  However, your best choice for reducing the risk of heart disease is following an anti-inflammatory diet.
Doctor Barry Sears

Dr. Sears Comments:

I think it is more reasonable to consume more polyphenols and omega-3 fatty acids foe maximal heart health, but call me crazy.
Doctor Barry Sears

Dr. Sears Comments:

 It's actually the balance of sodium to potassium that is key to controlling heart disease risk (O'Donnell MJ et al. "Urinary sodium and potassium excretion and risk of cardiovascular events.  JAMA 2011 Nov 23;306(20):2229-38")
Doctor Barry Sears

Dr. Sears Comments:

I would be concerned about diet-induced inflammation as the driving force for cancer.
Doctor Barry Sears

Dr. Sears Comments:

Since heart disease and diabetes are inflammatory disorders themselves, their association with other inflammatory disorders should not be too surprising.
Doctor Barry Sears

Dr. Sears Comments:

High-dose fish oil does wonders for both depression and heart disease regardless of gender. 
Doctor Barry Sears

Dr. Sears Comments:

It's not the sugar as much as the excess glucose.  The largest source of glucose in the diet is grain and starches.  Cut back on those as much as you cut back on sugar.
Doctor Barry Sears

Dr. Sears Comments:

The best way to manage any stage of cancer is to reduce inflammation.  If you add high-dose omega-3 fatty acids to the low-dose aspirin, you get an even greater benefit through the increased production of powerful anti-inflammatory hormones known as resolvins.
Doctor Barry Sears

Dr. Sears Comments:

The data are pretty clear that 1 oz. of nuts per day reduces cardiovascular mortality.  As you start to consume more nuts, then the problem of disposal of the excess fat becomes a problem.  I would stick with 30 grams of nuts per day.
Doctor Barry Sears

Dr. Sears Comments:

Interesting contrast of points of view.  Perhaps the man should have taken the ambulance to get the perception of more personal attention.  Of course, his wife probably got him to the hospital faster.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately the data suggests perhaps the opposite. The new generation of interesterfied fats indicates that they may increase insulin resistance. Simply frying the foods in vegetable oils generates toxic chemicals (HNE and others) that promote inflammation. Bottom line, don't eat fried food.
Doctor Barry Sears

Dr. Sears Comments:

Hello, is anyone home? The best way to reduce triglycerides is to take more fish oil. It's not the triglycerides that are related to heart disease, but an indication of insulin resistance (measured by the TG/HDL ratio) that is caused by cellular inflammation. I think I pointed this more than a decade ago in “The OmegaRx Zone.”

Doctor Barry Sears

Dr. Sears Comments:

That's true if you are using drugs to lower your blood pressure because they have side effects. That's not the case if you are using diet and exercise to reduce blood pressure.
Doctor Barry Sears

Dr. Sears Comments:

Here's one surprising thing to do to reduce a potential heart attack: Follow an anti-inflammatory diet and takes lots of fish oil.

Doctor Barry Sears

Dr. Sears Comments:

How about a little common sense? If you eat a high-fat diet, where is the excess fat going to go? It turns out it is going to be deposited in the liver if you believe Yale University. Also when the Atkins diet was compared in the Zone Diet in a highly controlled study published in the world premier nutritional research journal, the Zone Diet was shown to be superior in every regard except for increasing inflammation that the Atkins diet did an excellent job of in only six weeks.

Doctor Barry Sears

Dr. Sears Comments:

Before tinkering with vaccines for heart disease, it makes more sense to get people to follow an anti-inflammatory diet.
Doctor Barry Sears

Dr. Sears Comments:

Eventually, we are all going to die because of wear and tear on our systems or increased inflammation and usually a combination of both.
Doctor Barry Sears

Dr. Sears Comments:

Early menopause means an early increase in insulin levels as estrogen levels drop. If you are eating a diet rich in omega-6 fatty acids, this increases insulin levels and becomes a sure-fire prescription for increased inflammation that leads to increased risk of heart failure.
Doctor Barry Sears

Dr. Sears Comments:

Good luck in showing no side-effects of this type of drug in humans.