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Doctor Barry Sears

Dr. Sears Comments:

That's great, but you need a better treatment.  That treatment is high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Alzheimer's patients are easy targets for over prescription of drugs since many of those drugs reduce their aggression making them more docile and easier to take care of in a nursing home.
Doctor Barry Sears

Dr. Sears Comments:

Excellent point on olive oil and fish oil vs. saturated fats that is found in the correction to the widely quoted article that led to the media report that saturated fats are good. The data demonstrate that saturated fats cause inflammation, whereas olive oil and fish oil have more anti-inflammatory fats.
Doctor Barry Sears

Dr. Sears Comments:

I would call their "high-dose" barely beyond a placebo dose.
Doctor Barry Sears

Dr. Sears Comments:

Since neurons require omega-3 fatty acids for development in the fetus, lack of their presence in the mother's diet may be an underlying cause of altered neurodevelopment.
Doctor Barry Sears

Dr. Sears Comments:

The author forgot to mention that krill oil is extracted by gasoline (hexane) and then precipitated by nail polish remover (acetone) to get the final product.  I have analyzed krill, oil and it is also rich in PCBs.  Quite a bargain.
Doctor Barry Sears

Dr. Sears Comments:

18-HEPE is the building block for resolvins. You can make adequate levels of 18-HEPE as long as you keep your EPA levels greater than 4% of the total fatty acids in the blood. However, to reach that level of EPA in the blood you, need to take a lot of fish oil, like 5-7.5 grams of EPA and DHA per day. The average American consumes 0.125 grams per day.
Doctor Barry Sears

Dr. Sears Comments:

One of the best ways to manage ADHD is the use of high-dose fish oil to enhance dopamine levels.  One of my co-authors on our research published in 2007 is the leading authority on ADHD.  Somehow the popular press and the medical community seem to ignore his presence on this important piece of the ADHD puzzle.
Doctor Barry Sears

Dr. Sears Comments:

I agree that lowering salt is a good idea for everyone. An even better idea for MS patients is to lower inflammation by consuming more omega-3 fatty acids. I guess they should avoid salted herring. 
Doctor Barry Sears

Dr. Sears Comments:

A better game-changer is high-dose fish oil (Tavazzi L et al. "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial."  Lancet 2008 Oct 4;372(9645):1223-30)
Doctor Barry Sears

Dr. Sears Comments:

This is probably another case of fetal programming and helps explains the rapid rise in ADHD along with the dramatic decrease in the intake of omega-3 fatty acids (that also control depression better than anti-depressants). 
Doctor Barry Sears

Dr. Sears Comments:

I am glad that they mentioned my article that demonstrated a 98% reduction in nerve damage in an animal concussion model.  Too bad they didn't mention my article in treating comatose patients with severe brain trauma (Sears et al PharmaNutrition 1:86 (2013) using high-dose omega-3 fatty acids. 
Doctor Barry Sears

Dr. Sears Comments:

You are definitely gambling if your AA/EPA is not between 1.5 and 3.  Since the average American has an AA/EPA ratio of 18, I imagine Wes Welker is in that same range.
Doctor Barry Sears

Dr. Sears Comments:

Unlike this short abstract, a more comprehensive story on CBSnews.com at least recognized my published work on the benefits of high-dose omega-3 fatty acid supplementation in preventing brain damage in an animal concussion study.
Doctor Barry Sears

Dr. Sears Comments:

Diagnostic tests are good, but treatment is better.  High-dose fish oil is a very good treatment to reduce the neuroinflammation that remains after the initial concussion.
Doctor Barry Sears

Dr. Sears Comments:

ADHD is simply a deficiency of dopamine.  It is more epidemic today than it was a century ago.  That is most likely due to the growing deficiency of omega-3 fatty acids in today's diet that would otherwise increase dopamine levels in the brain.
Doctor Barry Sears

Dr. Sears Comments:

There is a strong indication that ALS is a neuro-inflammatory disease so increasing the intake of omega-3 fatty acids makes perfect scientific sense to reduce its development.
Doctor Barry Sears

Dr. Sears Comments:

The fetus needs omega-3 fatty acids for optimal brain development.  All fish have relatively high levels of PCBs as do fish oil in health-food stores.  Look for those brands that have a PCB level of less than 5 ppb (there aren't too many) as the ideal source of omega-3 fatty acids for the fetus.
Doctor Barry Sears

Dr. Sears Comments:

I guess no one at the FDA reads the published data on the use of high-dose fish oil to reduce concussion injuries in animal models.
Doctor Barry Sears

Dr. Sears Comments:

What is neglected in the article are the two great benefits of omega-3 fatty acids.  At low doses it help reduce the initiation of inflammation.  At higher doses it dramatically increases the resolution of existing inflammation.  You need both to live a healthy life.
Doctor Barry Sears

Dr. Sears Comments:

It is amazing how many Americans simply don't realize that most fish oil products are rich in PCBs due to the mistaken assumption that all fish oils are the same.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately, the author forgot to include PCB levels.  This is how you separate a health-food grade from the truly pharmaceutical-grade fish oil.
Doctor Barry Sears

Dr. Sears Comments:

It sounds like someone has been reading my books for the past 20 years.
Doctor Barry Sears

Dr. Sears Comments:

Ironically, one the best ways to treat depression and reduce the anxiety that leads to relapse in alcoholism is high-dose fish oil.  It you have either condition, the supplementation with high-dose fish oil will remarkably improve your ability to manage the condition. 
Doctor Barry Sears

Dr. Sears Comments:

Actually, there is a biological linkage between depression and Parkinson's.  It's called neuroinflammation.
Doctor Barry Sears

Dr. Sears Comments:

Fish oil has always been brain food and will continue to be brain food.  Unfortunately, the intake of long-chain omega-3 fatty acids has dropped by some 90-95% compared to 100 years ago.
Doctor Barry Sears

Dr. Sears Comments:

No need to worry since 85% of the crude fish oil goes to raising farmed-raised fish.  I would rather have humans getting the benefit of omega-3 fatty acids than cheaper salmon enriched with PCBs on my plate.
Doctor Barry Sears

Dr. Sears Comments:

I think it is easier to study a real brain.  When you do, you find that giving high doses of omega-3 fatty acids speeds up recovery by reducing neuroinflammation.
Doctor Barry Sears

Dr. Sears Comments:

It makes more sense to reverse macular degeneration by the use of high-dose fish oil than get ready for living in blindness and the depression that comes with that situation.
Doctor Barry Sears

Dr. Sears Comments:

Since PGD2 comes from arachidonic acid, doesn't it seem easier just to reduce arachidonic acid in the blood by the diet?  Call me crazy, but I think so.
Doctor Barry Sears

Dr. Sears Comments:

All of these interventions can reduce inflammation if you give therapeutic levels.
Doctor Barry Sears

Dr. Sears Comments:

Good dietary suggestions, but you are going to need fairly high levels of omega-3 fatty acids (5-7.5 grams of EPA and DHA per day) to have significant pain relief. 
Doctor Barry Sears

Dr. Sears Comments:

Surprisingly balanced article, however, there are great differences between short-chain omega-3 fatty acids (like alpha linolenic acid in chia seeds) and long-chain omega-3 fatty acids in salmon.  Ideally, you want your AA/EPA ratio to be between 1.5 and 3.
Doctor Barry Sears

Dr. Sears Comments:

It is only the ApoE4 gene variant that is related to Alzheimer's.  It appears that this gene variant decreases the transport of DHA into the brain (Vandal M et al.  "Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2." J Neurochem. 2014 May;129(3):516-26). Rather than blocking all ApoE actions, simply increase the dietary intake of DHA in those with ApoE4.
Doctor Barry Sears

Dr. Sears Comments:

Definitively not if you take adequate levels of omega-3 fatty acids as I demonstrated in my 2007 paper (Sorgi et al.  "Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder." Nutr J 2007;6:16) where one of my co-authors is the top ADHD expert in America.
Doctor Barry Sears

Dr. Sears Comments:

To maintain weight loss, you have to maintain a calorie-restricted diet.  Such a diet without adequate supplementation with long-chain omega-3 fatty acids can lead to depression.
Doctor Barry Sears

Dr. Sears Comments:

The more omega-3 fatty acids you consume, the more go to the brain.
Doctor Barry Sears

Dr. Sears Comments:

Children with ADHD have lower levels of omega-3 fatty acids than age-matched children.  When you give children with ADHD therapeutic levels of omega-3 fatty acids, their symptoms dramatically improved as I published in 2007. 
Doctor Barry Sears

Dr. Sears Comments:

 I would be very careful of unintended consequences of such plant genetics.
Doctor Barry Sears

Dr. Sears Comments:

Having more brain matter doesn't necessarily mean more intelligence, but it is a start.
Doctor Barry Sears

Dr. Sears Comments:

The article conveniently ignores the Japanese who are largest consumers of fish in the world with the greatest longevity, greatest health span, and low levels of depression and heart disease in the world.  The reason is their low AA/EPA ratio.  To get to that AA/EPA ratio in the Japanese, Americans need to consume between 5 and 7.5 grams of EPA and DHA per day.  No one does. The clinical trials often pointed to as lack of efficacy of fish oil use essentially placebo doses of omega-3 fatty acids.  No wonder they generate placebo results.
Doctor Barry Sears

Dr. Sears Comments:

Dementia is caused by neuroinflammation leading to neuronal death.  The omega-3 fatty acids can cross the blood-brain barrier easily to reduce neuroinflammation and therefore maintain brain volume.
Doctor Barry Sears

Dr. Sears Comments:

Low levels of fish intake help build the brain.  High levels of omega-3 fatty acids promote resolution of inflammation in the brain.
Doctor Barry Sears

Dr. Sears Comments:

Try to get real by focusing on the Japanese who are the largest consumers of fish oil in the world.  When you compare their health to that of Americas quantitatively by using the AA/EPA ratio in both populations, the reason for their superior long-term health is the fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Actually, Facebook does a pretty poor job of selling krill oil or any product, according to research.  This is because Facebook is still used a friends’ portal, and friends feel tacky acting as pitchmen to their friends.  This doesn't stop the high-powered sales presentations from being pushed onto marketers as the ultimate of advertising.
Doctor Barry Sears

Dr. Sears Comments:

As pointed out in the article, both MS and osteoporosis are inflammatory conditions.  This is why high-dose fish oil can be effective in treating both.
Doctor Barry Sears

Dr. Sears Comments:

At least the article hints at inflammation as the linkage of the two conditions.  The fact that high-dose fish oil treats both conditions would also reinforce that inflammatory link.
Doctor Barry Sears

Dr. Sears Comments:

The article was doing pretty good until it started called medium-chain triglycerides and saturated fats as healthy fat.  They also cause inflammation by binding to toll-like receptors.  If want healthy fats, omega-3 fats and monounsaturated fats are your primary choice.
Doctor Barry Sears

Dr. Sears Comments:

True if you use enough to reduce the neuroinflammation induced by the brain injury in the first place.
Doctor Barry Sears

Dr. Sears Comments:

A slight lack of details like how much fish oil they were taking.
Doctor Barry Sears

Dr. Sears Comments:

Inhibiting mTOR always prevents tumor growth.  Adding polyphenols to omega-3 does even a better job of reducing mTOR levels by increasing AMP kinase.
Doctor Barry Sears

Dr. Sears Comments:

That's why your grandmother called fish oil "brain food".
Doctor Barry Sears

Dr. Sears Comments:

Yes it does, but only if you take enough to reduce inflammation in the brain.  That usually requires a lot of omega-3 fatty acids.  Therefore, it has to be very low in PCBs, which unfortunately is not the case when you go to a health- food store or supermarket.
Doctor Barry Sears

Dr. Sears Comments:

Like treating severe brain trauma, if omega-3 fatty acids are to be effective, they must be used at high doses.
Doctor Barry Sears

Dr. Sears Comments:

When you give placebo doses of fish oil, you get placebo results.  The same is true of drugs.
Doctor Barry Sears

Dr. Sears Comments:

The benefits are likely due to increased levels of resolvins that shut down ongoing inflammation.
Doctor Barry Sears

Dr. Sears Comments:

The answer is pathetic.  More than 99% of Alzheimer's fail, and those that "work" don't work very well.  With our current diabetes epidemic plan for an Alzheimer's tsunami in 20 years.  However, since Alzheimer's is an inflammatory disease, it makes sense that an anti-inflammatory diet, highly enriched in anti-inflammatory omega-3 fatty acids may be our only drug in the future.
Doctor Barry Sears

Dr. Sears Comments:

Of the listed treatments, high-dose fish oil is the best since dry eye is an inflammatory condition that is best treated by anti-inflammatory omega-3 fatty acids.
Doctor Barry Sears

Dr. Sears Comments:

The real science behind TBI recovery is the reduction of neuroinflammation caused by the TBI in the first place.  The best "drug" for that remains high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Maybe there is just a need for some common sense.  If Alzheimer's is an inflammatory disease, doesn't it make sense taking high doses of anti-inflammatory omega-3 fatty acids that can get into the brain should be the primary treatment?
Doctor Barry Sears

Dr. Sears Comments:

I continually find it difficult to understand when there has been peer-reviewed research for nearly a decade demonstrating that high-dose fish oil effectively manages ADHD, yet physicians ignore the research.  So much for "evidence-based medicine."
Doctor Barry Sears

Dr. Sears Comments:

I think it is more reasonable to consume more polyphenols and omega-3 fatty acids foe maximal heart health, but call me crazy.
Doctor Barry Sears

Dr. Sears Comments:

The clinical data on high-dose fish oil to treat mild to severe depression is much stronger than St. John's wort.  Why not stick with a winner?
Doctor Barry Sears

Dr. Sears Comments:

Since I was mentioned in the article, I should set the record straight that a "pharmaceutical-grade" fish oil is one that has PCB levels of less than 5 ppb (that’s a very low level).  If a company doesn't post the PCB levels in every lot of fish oil they sell, there is usually a good reason.
Doctor Barry Sears

Dr. Sears Comments:

If you have had a brain injury, taking high-dose omega-3 fatty acids to reduce the neuroinflammation it has caused is probably your best protection against early Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

High-dose fish oil does wonders for both depression and heart disease regardless of gender. 
Doctor Barry Sears

Dr. Sears Comments:

The best way to manage any stage of cancer is to reduce inflammation.  If you add high-dose omega-3 fatty acids to the low-dose aspirin, you get an even greater benefit through the increased production of powerful anti-inflammatory hormones known as resolvins.
Doctor Barry Sears

Dr. Sears Comments:

Of all the "superfoods" to be incorporated into an anti-inflammatory diet, chia seeds would definitely be a B player.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately, 95% of all salmon is farm-raised, which is rich in PCBs compared to wild salmon.  That is why wild salmon is so expensive
Doctor Barry Sears

Dr. Sears Comments:

The studies with FAT-1 transgenic mice indicate to get the anti-cancer benefits in humans requires the AA/EPA ratio to be approximately 1.  The current average AA/EPA ratio for Americans is 20.  That means they need a lot of fish oil. 
Doctor Barry Sears

Dr. Sears Comments:

This is true for all medications. Rather than treating the cause, the usual medical response is adding more drugs.
Doctor Barry Sears

Dr. Sears Comments:

There are more than 50 polyphenols in red wine, and more than 8,000 known polyphenols. Just because resveratrol has the highest concentration in red wine doesn't mean it is the most important. In fact, a minor polyphenol (delphinidins) in red wine has been shown to be more powerful than resveratrol in reducing inflammation. It's the reduction in inflammation that reduces deaths, heart disease, and cancer.

Doctor Barry Sears

Dr. Sears Comments:

The real enemy in treating obesity comes from using simple slogans. It's not fat or sugar per se, but the combination of insulin and omega-6 fatty acids that increase inflammation in the adipose tissue that cause the expansion and eventual metastasis (like a cancer) of fat to other organs as I described in my book "Toxic Fat."

Doctor Barry Sears

Dr. Sears Comments:

High-dose fish oil good for treating depression in both males and females. It also makes you happier.

Doctor Barry Sears

Dr. Sears Comments:

Both ADHD drugs and high-dose fish oil increase dopamine levels. The high-dose fish oil can reduce many of symptoms of menopause, such as hot flashes. I would stick with the high-dose fish oil.

Doctor Barry Sears

Dr. Sears Comments:

I believe the W.H.O. recommendations for omega-3 intakes are about 10 times too low.
Doctor Barry Sears

Dr. Sears Comments:

The differences may be due to estrogen levels. But in any case, it takes a long time for a complete recovery. High-dose fish oil will reduce that recovery time for either sex by reducing neuroinflammation.

Doctor Barry Sears

Dr. Sears Comments:

Only about 5% of the short chain omega-3 fatty acids in flaxseed oil get converted to EPA and even less to DHA (about 1%). Only EPA and DHA provide the anti-inflammatory effects of omega-3 fatty acids. Since I recommend about 1600 mg of EPA per day, this means you need to consume about 64 grams of flaxseed oil per day to get that level of EPA. Relative to getting enough DHA, I agree with the article that purchasing an algae form is the most cost-effective approach. However you will need about 800 mg per day to meet my minimum requirements for DHA.

Doctor Barry Sears

Dr. Sears Comments:

The omega-3 fatty acids are fine, it's just the mercury in the tuna and the glucose in the sandwich that are less desirable.
Doctor Barry Sears

Dr. Sears Comments:

If you give a placebo dose of omega-3 fatty acids, you tend to get placebo effects.
Doctor Barry Sears

Dr. Sears Comments:

I simply tell people let the blood determine how much EPA and DHA you need. Take enough to keep the AA/EPA ratio between 1.5 and 3.

Doctor Barry Sears

Dr. Sears Comments:

It's a little more complicated than simply chocolate. It is the cocoa polyphenols most which are destroyed in making chocolate.
Doctor Barry Sears

Dr. Sears Comments:

I wish it were a fad, but it's indicative of the growing neurological problems that dietary changes have induced in our population. These epigenetic changes are not going away very soon.
Doctor Barry Sears

Dr. Sears Comments:

When The Mediterranean Zone appears in September, the real science behind the Mediterranean diet will be explained.
Doctor Barry Sears

Dr. Sears Comments:

Even the algae oil sold for human consumption is genetically modified.
Doctor Barry Sears

Dr. Sears Comments:

Once such mediation to lower stress is high-dose fish oil.
Doctor Barry Sears

Dr. Sears Comments:

Stroke recovery is governed by reducing inflammation. Depression is linked with increased inflammation.

Doctor Barry Sears

Dr. Sears Comments:

Too bad there was no mention of reducing inflammation in their fat cells.
Doctor Barry Sears

Dr. Sears Comments:

Cardiovascular conditions like heart failure are linked to increased inflammation. So is depression.