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Doctor Barry Sears

Dr. Sears Comments:

This is a consequence of fetal programming in which hyperinsulinemia can leave epigenetic marks in the DNA of the fetus that predisposes them to obesity, diabetes, and diabetes.  Much of this is explained in my new book, “The Mediterranean Zone,” coming out in the fall.
Doctor Barry Sears

Dr. Sears Comments:

Diabetes also fuels heart disease and Alzheimer's.  It's not the diabetes, but the inflammation that compromises the immune system.
Doctor Barry Sears

Dr. Sears Comments:

t's not that simple.  It is obesity becoming metabolic syndrome (pre-diabetes) then going on to type-2 diabetes.  The progression is caused by the flow of inflammation from the fat cells to the liver to the pancreas.
Doctor Barry Sears

Dr. Sears Comments:

You don't get diabetes by being fat. You get diabetes by first developing metabolic syndrome (pre-diabetes) before the beta cells in the pancreas are destroyed causing diabetes. Both metabolic syndrome and diabetes are caused by increased inflammation. If you are fat and not inflamed, you fall into the category of "metabolically healthy obese" which is about 20-30% of the obese population. 
Doctor Barry Sears

Dr. Sears Comments:

The benefits of pistachios come from the polyphenols in the nuts. The reason the weight didn't change is because of the concentration of fat in the nuts.
Doctor Barry Sears

Dr. Sears Comments:

Low birth weight causes a catch-up phase marked by increased insulin secretion. It is excess insulin that makes you fat and keeps you fat.
Doctor Barry Sears

Dr. Sears Comments:

This is due to fetal programing that sets epigenetic marks that will last a lifetime.  My new book, “The Mediterranean Zone,” goes into more detail how this happens.
Doctor Barry Sears

Dr. Sears Comments:

Stress causes inflammation, and inflammation accelerates diabetes.
Doctor Barry Sears

Dr. Sears Comments:

The best way to treat diabetes and prevent hypoglycemia remains an anti-inflammatory diet and exercise.
Doctor Barry Sears

Dr. Sears Comments:

I would follow the Joslin Diabetes’ Center’s at Harvard Medical School dietary guidelines since they are essentially the Zone Diet.
Doctor Barry Sears

Dr. Sears Comments:

Any time you compare a high-carbohydrate diet to a ketogenic low-carbohydrate diet in diabetics, the low-carb diet wins in the short term.  Unfortunately, diabetes is long-term disease.  The longer you stay on a ketogenic diet, the more cortisol levels begin to increase to cause weight regain.  What you need is an anti-inflammatory diet that has a balance between protein and the glycemic load.
Doctor Barry Sears

Dr. Sears Comments:

It is the potassium-to-sodium ratio that is more important than total sodium.  The best way to increase potassium is to eat more vegetables and fruits.  For diabetics, this lowering of the glycemic load of the diet is the best defense against heart disease.
Doctor Barry Sears

Dr. Sears Comments:

Actually depression is like diabetes as both conditions have a strong inflammatory component working in different directions.  In diabetes, the inflammation is disrupting normal glucose metabolism, whereas in depression the inflammation is disturbing the flow of neural transmitters.
Doctor Barry Sears

Dr. Sears Comments:

Hippocrates’ quote should be updated to read "Let Food Be Thy Modulator of Hormone Response and Gene Expression."
Doctor Barry Sears

Dr. Sears Comments:

The drug mentioned in the article has a few side effects like bladder cancer.  You can replicate the benefits of TZD with high-dose polyphenols or high-dose omega-3 fatty acids since they activate the same gene transcription factor. 
Doctor Barry Sears

Dr. Sears Comments:

This assumes they are also following an anti-inflammatory diet.  Then they all work together.
Doctor Barry Sears

Dr. Sears Comments:

Both diseases are driven by inflammation as is described in greater detail in my new book, “The Mediterranean Zone,” that comes out in September.
Doctor Barry Sears

Dr. Sears Comments:

The drugs used for treating type 2 diabetes can have significant side effects.  The best "drug" remains an anti-inflammatory diet that treats the underlying cause of diabetes.
Doctor Barry Sears

Dr. Sears Comments:

When you are dealing with drug treatment, I agree.  However, lifestyle intervention can lower blood glucose far more effectively than drugs with better long-term results.
Doctor Barry Sears

Dr. Sears Comments:

Since heart disease and diabetes are inflammatory disorders themselves, their association with other inflammatory disorders should not be too surprising.
Doctor Barry Sears

Dr. Sears Comments:

It's not the sugar as much as the excess glucose.  The largest source of glucose in the diet is grain and starches.  Cut back on those as much as you cut back on sugar.
Doctor Barry Sears

Dr. Sears Comments:

Unfortunately the data suggests perhaps the opposite. The new generation of interesterfied fats indicates that they may increase insulin resistance. Simply frying the foods in vegetable oils generates toxic chemicals (HNE and others) that promote inflammation. Bottom line, don't eat fried food.
Doctor Barry Sears

Dr. Sears Comments:

Some of that depression can come from over-medication that can push blood glucose levels too low.
Doctor Barry Sears

Dr. Sears Comments:

This gene may an epigenetic adaptation to the low-carbohydrate environment.
Doctor Barry Sears

Dr. Sears Comments:

A 300% increase in pre-diabetes in only eight years is remarkable. It only indicates that cellular inflammation induced by the diet knows no boundaries.

Doctor Barry Sears

Dr. Sears Comments:

The best way to prevent and treat heart disease is to reduce inflammation in the heart tissue.
Doctor Barry Sears

Dr. Sears Comments:

A nearly 12% increase in diabetes in 3 years is remarkable. So will be the corresponding increases in Alzheimer's that is greater enhanced once diabetes is established.

Doctor Barry Sears

Dr. Sears Comments:

Anything that reduces inflammation will reduce the development of type 2 diabetes.
Doctor Barry Sears

Dr. Sears Comments:

Even if you know you have diabetes, you are 2-4 times more likely to get a heart attack or develop Alzheimer’s.
Doctor Barry Sears

Dr. Sears Comments:

This should quell some of the enthusiasm for putting statins in the drinking water because of their "safety". Also, a recent study has indicated that statins decrease physical activity because of their impact on muscle weakness and decreased production of ATP.

Doctor Barry Sears

Dr. Sears Comments:

The best way to manage gestational diabetes is also the best way to manage diabetes in general: Follow an anti-inflammatory diet.
Doctor Barry Sears

Dr. Sears Comments:

The hormone GLP-1 that is increased by the drug can also be enhanced by lowering the glycemic load of the diet. Here's your choice: inject a drug or eat lots of vegetables.

Doctor Barry Sears

Dr. Sears Comments:

The disconnect is the gene mutation is rare, but metabolic syndrome is not. More than 79 million American have metabolic syndrome and if left untreated, then in 8-10 years it develops into type 2 diabetes. Once you have diabetes you are 2-4 times more likely to get a heart attack and twice as likely to get Alzheimer's.

Doctor Barry Sears

Dr. Sears Comments:

There is a very good reason that ADHD drugs are Schedule III drugs. The more you use them, the less the brain can normally process information and to maintain focus. A more effective way to increase dopamine (the goal of ADHD drugs) is to take high-dose fish oil. That's why high-dose fish oil is so effective in treating ADHD.

Doctor Barry Sears

Dr. Sears Comments:

A smaller hippocampal size is also associated with lower levels of omega-3 fatty acids in the blood. Perhaps, not surprisingly, supplementation with high-dose omega-3 fatty acids removes the rate of healing from severe brain trauma.

Doctor Barry Sears

Dr. Sears Comments:

Here is an even more novel idea to reduce heart disease: Combine increased exercise with an anti-inflammatory diet.
Doctor Barry Sears

Dr. Sears Comments:

Although often considered a female hormone, males have similar levels of this steroid in their blood. Progesterone is often used in treating severe brain trauma. The results of a Phase-3 trial are due to be released this month.

Doctor Barry Sears

Dr. Sears Comments:

And that is only up to 2009. It's probably worse now, which doesn't bode well for future health care since once you have diabetes you are 2-4 times more likely to develop heart disease and Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

Really it's the polyphenols. Coffee is the primary source of polyphenols for most Americans. To get the real benefits, you need about 1 gram of polyphenols per day. A typical cup of coffee supplies about 100 mg.
Doctor Barry Sears

Dr. Sears Comments:

Tied to Preterm Birth. Both can be linked to hyperinsulinemia.
Doctor Barry Sears

Dr. Sears Comments:

The global diabetes epidemic is just the start of a global Alzheimer's epidemic.
Doctor Barry Sears

Dr. Sears Comments:

Take it one step further and simply follow an anti-inflammatory diet for life.
Doctor Barry Sears

Dr. Sears Comments:

As those associated risks of diabetes drop, Alzheimer's continues to increase. Be careful what you wish for.
Doctor Barry Sears

Dr. Sears Comments:

It generally increases the future likelihood of obesity, diabetes and heart disease because of the hyperinsulinemia it creates in the fetus.
Doctor Barry Sears

Dr. Sears Comments:

Fatty liver is the next epidemic rising in America. Like diabetes and atherosclerosis it's primary cause is increased inflammation.
Doctor Barry Sears

Dr. Sears Comments:

It is very hard to talk about advances in treating diabetes because it has increased by 200% since 1990 according to a recent article in the Annals of Medicine. As a chronic disease, it is a money-makier for the drug companies.