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Doctor Barry Sears

Dr. Sears Comments:

I really get tired of one after another epidemiological study touting Vitamin D.  The intervention trials have generated pathetic results.  Vitamin D levels are simply a marker of good general health.
Doctor Barry Sears

Dr. Sears Comments:

Stick with the polyphenols in extra-virgin olive oil and the omega-3 fatty acids in salmon, but you need therapeutic amounts of both to reduce neuro-inflammation.  As far the MIT "brain drink," save your money and taste buds.
Doctor Barry Sears

Dr. Sears Comments:

Since PGD2 comes from arachidonic acid, doesn't it seem easier just to reduce arachidonic acid in the blood by the diet?  Call me crazy, but I think so.
Doctor Barry Sears

Dr. Sears Comments:

It is only the ApoE4 gene variant that is related to Alzheimer's.  It appears that this gene variant decreases the transport of DHA into the brain (Vandal M et al.  "Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2." J Neurochem. 2014 May;129(3):516-26). Rather than blocking all ApoE actions, simply increase the dietary intake of DHA in those with ApoE4.
Doctor Barry Sears

Dr. Sears Comments:

Interesting observation, but as pointed out in the article, there is large leap from mice to men since we are about 60 million years apart in evolution.
Doctor Barry Sears

Dr. Sears Comments:

In essence, drug companies still have no clue as to what causes Alzheimer's, and that's why 99% of all new Alzheimer's drugs fail, and the ones that are approved don't work very well.
Doctor Barry Sears

Dr. Sears Comments:

Since both Alzheimer's and Parkinson's are inflammatory diseases, it makes sense to search for a compound that easily crosses the blood-brain barrier and reduces the inflammation in the brain.  That compound already exists.  It's called fish oil.  What you have to do is to give enough of it to work.  No brain bank required.
Doctor Barry Sears

Dr. Sears Comments:

The drug mentioned in the article has a few side effects like bladder cancer.  You can replicate the benefits of TZD with high-dose polyphenols or high-dose omega-3 fatty acids since they activate the same gene transcription factor. 
Doctor Barry Sears

Dr. Sears Comments:

Not surprisingly, the same is true for diabetes.  That's why if you have diabetes, you are twice as likely to develop Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

The answer is pathetic.  More than 99% of Alzheimer's fail, and those that "work" don't work very well.  With our current diabetes epidemic plan for an Alzheimer's tsunami in 20 years.  However, since Alzheimer's is an inflammatory disease, it makes sense that an anti-inflammatory diet, highly enriched in anti-inflammatory omega-3 fatty acids may be our only drug in the future.
Doctor Barry Sears

Dr. Sears Comments:

Both diseases are driven by inflammation as is described in greater detail in my new book, “The Mediterranean Zone,” that comes out in September.
Doctor Barry Sears

Dr. Sears Comments:

Maybe there is just a need for some common sense.  If Alzheimer's is an inflammatory disease, doesn't it make sense taking high doses of anti-inflammatory omega-3 fatty acids that can get into the brain should be the primary treatment?
Doctor Barry Sears

Dr. Sears Comments:

Diabetes is known to cause brain shrinkage, and exercise is very effective for reducing elevated blood-sugar levels.  Since 26% of Americans over age 65 have diabetes, the best recommendation should be constant exercise after age 65.
Doctor Barry Sears

Dr. Sears Comments:

If you have had a brain injury, taking high-dose omega-3 fatty acids to reduce the neuroinflammation it has caused is probably your best protection against early Alzheimer's.
Doctor Barry Sears

Dr. Sears Comments:

It's low triglycerides that are the medical "breakthrough". The best way to maintain low triglycerides is an anti-inflammatory diet supplemented with high levels of omega-3 fatty acids.

Doctor Barry Sears

Dr. Sears Comments:

At least the amyloid theory is losing stream, but nowhere in the article was there any discussion of neuroinflammation that can be reduced by high-dose fish oil. It's also possible the higher levels of omega-3 fatty acids would modify the ApoE4-binding patterns to its receptor.

Doctor Barry Sears

Dr. Sears Comments:

Omega-3 fatty acids are effective, but you need to take a therapeutic dosage.

Doctor Barry Sears

Dr. Sears Comments:

This is a fascinating article on the use of optical waves to erase and retrieve memories. The implications are actually quite scary.

Doctor Barry Sears

Dr. Sears Comments:

This is why it is always better to get multiple blood-pressure readings. Ideally, have a home machine if you are really concerned.

Doctor Barry Sears

Dr. Sears Comments:

An even better treatment for Alzheimer's instead of deep brain stimulation would be high-dose omega-3 fatty acids.
Doctor Barry Sears

Dr. Sears Comments:

Let's not forgot diabetes. An article in the December 2013 issue of Diabetes Care (Moran et al) demonstrated the longer you have diabetes, the more atrophy you see in the brain with a corresponding increase in loss of cognitive function.

Doctor Barry Sears

Dr. Sears Comments:

On the other hand, a blood test for the levels of omega-3 fatty acids in the blood would be highly ethical since there is something you can do for it.
Doctor Barry Sears

Dr. Sears Comments:

It's sad that the government is looking at failed drugs to treat Alzheimer's instead of looking at high-dose fish oil to reduce neuroinflammation in the brain.