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Inflammation Research Foundation

In 2003, Dr. Sears founded the Inflammation Research Foundation (IRF), a non-profit 501(c) foundation dedicated and committed to providing resources and grants for both education and medical research projects. With contributions coming primarily from Dr. Sears, the Inflammation Research Foundation funds short-term clinical research studies aimed at using new nutritional interventions to manage chronic diseases associated with inflammation. Since funding at the government level is highly limited, this is a resource that researchers can use to gather the preliminary data they need to get future funding at the government level. In addition, it affords researchers more latitude with the scope of the trials they choose to conduct. Dr. Sears surrounds himself by researchers whose expertise has much to offer the field of anti-inflammatory nutrition. These individuals among others comprise his Scientific Advisory Board. The peer-reviewed studies that follow come from Dr. Sears' years of personal research along with the contributions to the medical field from the Inflammation Research Foundation.


  1. Bell, S.J. and Sears, B. “Low-glycemic load diets: Impact on obesity and chronic diseases.” Crit Rev Food Sci and Nutr 43: 357-377 (2003)
  2. Bell SJ and Sears B. "A Proposal for a New National Diet: A Low Glycemic- Load Diet with a Unique Macronutrient Composition." Metabol Synd and Related Disord 1:199-208 (2003).
  3. Bell SJ and Sears B. “The Zone Diet: An Anti-Inflammatory, Low Glycemic-Load Diet.” Metabol Synd and Related Disord 2:24-38 (2004).
  4. Johnston CS, Tjonn S, Swan PD, White A, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets.” Am J Clin Nutr 83: 1055-1061 (2006)
  5. Johnston CS, Tjonn SL, Swan PD, White A, and Sears B. “Low-carbohydrate, high-protein diets that restrict potassium-rich fruits and vegetables promote calciuria.” Osteoporos Int 17: 1820-1821 (2006)
  6. Johnston, CS, White AM, Tjonn, S, Swan PD, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. Reply to NJ Krilanovich.” Am J Clin Nutr 85: 239 (2007)
  7. Sorgi PJ, Hallowell EM, Hutchins HL, and Sears B. “Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder Nutr J 13:16 (2007)
  8. White AM, Johnston CS, Swan PD, Tjonn SL, and Sears B. “Blood ketones are directly related to fatigue and perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss: A pilot study.” J Am Diet Assoc 107: 1792-1796 (2007)
  9. Sears B. “Anti-inflammatory diets for obesity and diabetes.” J Coll Amer Nutr 28: 482S-491S (2009)
  10. Mills JD, Bailes JE, Sedney CL, Hutchins H, and Sears B. “Omega-3 dietary supplementation reduces traumatic axonal injury in a rodent head injury model”. J Neurosurgery 114: 77-84 (2011)
  11. Sears B and Ricordi C. “Anti-inflammatory nutrition as a pharmacological approach to treat obesity.” J Obesity 2011: 431985 (2011)
  12. Sears B and Ricordi C. “Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome, and diabetes.” Eur Rev Med Pharmacol Sci 16: 1137-1154 (2012)
  13. Lotrich, FE, Sears, B, and McNamara RK. “Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: Relationship with interleukin-6.” Brain, Behavior, and Immunity 31: 48-53 (2013)
  14. Sears B, Bailes J, and Asselin B. “Therapeutic uses of high-dose omega-3 fatty acids to treat comatose patients with severe brain injury.” PharmaNutrition 1: 86-89 (2013)
  15. Lotrich FE, Sears B, and McNamara R.K. “Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids.” J Psychosomatic Res 75:475-483 (2013)
  16. McNamara RK, Perry M, and Sears, B. “Dissociation of C-reactive protein levels from long-chain omega-3 fatty acid status and anti-depressant response in adolescents with major depressive disorder: an open-label dose-ranging trial.” J Nutr Therapeutics 2:235-243 (2013)
  17. Georgiou T, Neokleous A, Nikolaou D, and Sears B. "Pilot study for treating dry age-related macular degeneration (AMD) with high-dose omega-3 fatty acids.” PharmaNutrition 2:8-11 (2014)